Publications

Genetics in medicine : official journal of the American College of Medical Genetics

Using a gene expression signature when controversy exists regarding the indication for adjuvant systemic treatment reduces the proportion of patients receiving adjuvant chemotherapy: a nationwide study.

01-07-2016

Journal of structural biology

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.

01-07-2016

Cell

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.

30-06-2016

Ecancermedicalscience

The steady progress of targeted therapies, promising advances for lung cancer.

29-06-2016

Proceedings of the National Academy of Sciences of the United States of America

Defining chromosomal translocation risks in cancer.

28-06-2016

Cancer informatics

The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care.

28-06-2016

Cell reports

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

28-06-2016

Nederlands tijdschrift voor geneeskunde

[Radiotherapy in Europe].

24-06-2016

Acta oncologica (Stockholm, Sweden)

Neurocognitive function of lymphoma patients after treatment with chemotherapy.

23-06-2016

Oncotarget

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling.

21-06-2016

Breast cancer research : BCR

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

21-06-2016

Trials

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.

21-06-2016

Scientific reports

OncoScape: Exploring the cancer aberration landscape by genomic data fusion.

20-06-2016

JAMA

Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer

19-06-2016

Key

mSphere

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

16-06-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.

15-06-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma.

15-06-2016

Genes & development

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

15-06-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab.

15-06-2016

BMC cancer

Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry.

11-06-2016

Science (New York, N.Y.)

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

10-06-2016

Nature communications

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

10-06-2016

Health and quality of life outcomes

Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain.

07-06-2016

Oncotarget

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

07-06-2016

Journal of pharmaceutical and biomedical analysis

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

05-06-2016

Nucleic acids research

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

02-06-2016

Nature

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

02-06-2016

Cancer immunology, immunotherapy : CII

Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.

01-06-2016

Investigational new drugs

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison.

01-06-2016

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients.

01-06-2016

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Prospectively measured lifestyle factors and BMI explain differences in health-related quality of life between colorectal cancer patients with and without comorbid diabetes.

01-06-2016

Journal of genetic counseling

Communication Between Breast Cancer Patients Who Received Inconclusive Genetic Test Results and Their Daughters and Sisters Years After Testing.

01-06-2016

Clinical & experimental metastasis

Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options.

01-06-2016

Urologic oncology

Baseline tumor volume in assessing prognosis of patients with intermediate-risk synchronous metastatic renal cell carcinoma.

01-06-2016

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

MRI-guided prostate adaptive radiotherapy - A systematic review.

01-06-2016

Psycho-oncology

Patients are dissatisfied with information provision: perceived information provision and quality of life in prostate cancer patients.

01-06-2016

International journal of radiation oncology, biology, physics

Intrafraction Motion in Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer: Intensity Modulated Radiation Therapy Versus Volumetric Modulated Arc Therapy.

01-06-2016

Journal of pharmacokinetics and pharmacodynamics

The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

01-06-2016

Cardiovascular research

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

01-06-2016

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Decisions on Further Research for Predictive Biomarkers of High-Dose Alkylating Chemotherapy in Triple-Negative Breast Cancer: A Value of Information Analysis.

01-06-2016

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Treatment outcome of supraglottoplasty vs. wait-and-see policy in patients with laryngomalacia.

01-06-2016

Frontiers in bioscience (Landmark edition)

Invadosomes - shaping actin networks to follow mechanical cues.

01-06-2016

International journal of radiation oncology, biology, physics

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From 2 Prospective Cohorts.

01-06-2016

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Chemotherapy-induced neuropathy in multiple myeloma: influence on quality of life and development of a questionnaire to compose common toxicity criteria grading for use in daily clinical practice.

01-06-2016

Biochimica et biophysica acta

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis.

01-06-2016

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Hearing loss in survivors of childhood head and neck rhabdomyosarcoma: a long-term follow-up study.

01-06-2016

European journal of clinical pharmacology

Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment.

01-06-2016

Current opinion in structural biology

Editorial overview: New constructs and expression of proteins.

01-06-2016

Nature biotechnology

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

01-06-2016

International journal of cancer

Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity.

01-06-2016