Publications

Pharmacological research

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

01-12-2015

The Lancet. Oncology

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.

01-12-2015

EJNMMI physics

Clinical evaluation of respiration-induced attenuation uncertainties in pulmonary 3D PET/CT.

01-12-2015

Cancer treatment reviews

The use of combinations of monoclonal antibodies in clinical oncology.

01-12-2015

Familial cancer

Prevalence and detection of psychosocial problems in cancer genetic counseling.

01-12-2015

Medical physics

A 1.5 T transverse magnetic field in radiotherapy of rectal cancer: Impact on the dose distribution.

01-12-2015

EMBO reports

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

01-12-2015

Molecular oncology

Tumor-infiltrating lymphocytes for the treatment of metastatic cancer.

01-12-2015

Current colorectal cancer reports

Treatment Individualization in Colorectal Cancer.

01-12-2015

Science (New York, N.Y.)

Gene essentiality and synthetic lethality in haploid human cells.

27-11-2015

Journal of medical Internet research

Empowerment of Cancer Survivors Through Information Technology: An Integrative Review.

27-11-2015

JMIR cancer

Effect of Web-Based Versus Paper-Based Questionnaires and Follow-Up Strategies on Participation Rates of Dutch Childhood Cancer Survivors: A Randomized Controlled Trial.

24-11-2015

Nature

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

19-11-2015

eLife

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

14-11-2015

BMC cancer

Return-to-work intervention for cancer survivors: budget impact and allocation of costs and returns in the Netherlands and six major EU-countries.

12-11-2015

Oncotarget

SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.

10-11-2015

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.

01-11-2015

Nature medicine

The consensus molecular subtypes of colorectal cancer.

01-11-2015

Human brain mapping

Lower cognitive performance and white matter changes in testicular cancer survivors 10 years after chemotherapy.

01-11-2015

Carcinogenesis

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence.

01-11-2015

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The course of fatigue and its correlates in colorectal cancer survivors: a prospective cohort study of the PROFILES registry.

01-11-2015

Breast cancer research and treatment

Molecular subtyping improves diagnostic stratification of patients with primary breast cancer into prognostically defined risk groups.

01-11-2015

Acta oncologica (Stockholm, Sweden)

Recent trends and predictors of multimodality treatment for oesophageal, oesophagogastric junction, and gastric cancer: A Dutch cohort-study.

01-11-2015

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Impact of tumour invasion on seminal vesicles mobility in radiotherapy of prostate cancer.

01-11-2015

Journal of the National Cancer Institute

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.

01-11-2015

Journal of immunology (Baltimore, Md. : 1950)

Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.

01-11-2015

Journal of immunology (Baltimore, Md. : 1950)

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage.

01-11-2015

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Impact of an Automatically Generated Cancer Survivorship Care Plan on Patient-Reported Outcomes in Routine Clinical Practice: Longitudinal Outcomes of a Pragmatic, Cluster Randomized Trial.

01-11-2015

Acta crystallographica. Section D, Biological crystallography

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

01-11-2015

Nature protocols

Using the GEMM-ESC strategy to study gene function in mouse models.

01-11-2015

The Journal of allergy and clinical immunology

Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency.

01-11-2015

European journal of cancer (Oxford, England : 1990)

Prognostic impact of immune response in resectable colorectal liver metastases treated by surgery alone or surgery with perioperative FOLFOX in the randomised EORTC study 40983.

01-11-2015

European journal of cancer (Oxford, England : 1990)

The influence of prior novel androgen receptor targeted therapy on the efficacy of cabazitaxel in men with metastatic castration-resistant prostate cancer.

01-11-2015

EMBO molecular medicine

Androgen receptor profiling predicts prostate cancer outcome.

01-11-2015

Nature genetics

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

01-11-2015

Cell cycle (Georgetown, Tex.)

Tumor heterogeneity-induced signaling regulates SCLC metastasis.

29-10-2015

Frontiers in immunology

Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy.

27-10-2015

Proceedings of the National Academy of Sciences of the United States of America

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

27-10-2015

Journal of cell science

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.

15-10-2015

International journal of cancer

ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.

15-10-2015

Journal of cell science

The molecular architecture of hemidesmosomes, as revealed with super-resolution microscopy.

15-10-2015

Science (New York, N.Y.)

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.

09-10-2015

Biomarkers in medicine

Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: a systematic review and meta-analysis.

07-10-2015

Mobile genetic elements

Applications of DNA integrating elements: Facing the bias bully.

07-10-2015

Cell reports

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

06-10-2015

Molecular pharmaceutics

P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.

05-10-2015

Oncogenesis

MiR expression profiles of paired primary colorectal cancer and metastases by next-generation sequencing.

05-10-2015

Breast cancer research : BCR

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response.

03-10-2015

Journal of proteome research

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

02-10-2015

Clinical cancer research : an official journal of the American Association for Cancer Research

Translating Pembrolizumab to Clinical Practice: Speak Immunology and Learn Fast!

01-10-2015