Publications

Investigational new drugs

Human mass balance study and metabolite profiling of ¹⁴C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.

01-12-2017

JAMA oncology

Surveillance of Dutch Patients With Li-Fraumeni Syndrome: The LiFe-Guard Study.

01-12-2017

Oral oncology

Definitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity.

01-12-2017

Thrombosis and haemostasis

Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry.

01-12-2017

Hepatology (Baltimore, Md.)

In vivo veritas: Finding novel genes involved in liver cancer through in vivo genetic screens.

01-12-2017

Breast cancer research and treatment

BRCA1-like profile is not significantly associated with survival benefit of non-myeloablative intensified chemotherapy in the GAIN randomized controlled trial.

01-12-2017

Journal of surgical oncology

Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.

01-12-2017

The oncologist

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.

01-12-2017

International wound journal

Assessing and comparing the quality of wound centres: a literature review and benchmarking pilot.

01-12-2017

Reproductive biomedicine online

Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy.

01-12-2017

Annals of surgical oncology

In Reply: Centralization of Upper Gastrointestinal Cancer Care Should Be Dictated by Quality of Care.

01-12-2017

Annals of surgical oncology

Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.

01-12-2017

Nature genetics

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

01-12-2017

European radiology

MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery.

01-12-2017

Journal of the National Cancer Institute

Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure.

01-12-2017

JAMA oncology

Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

01-12-2017

Nature communications

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

30-11-2017

Oncotarget

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.

28-11-2017

ACS nano

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.

28-11-2017

ESMO open

Targeting immune checkpoints in breast cancer: an update of early results.

28-11-2017

Cell cycle (Georgetown, Tex.)

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.

22-11-2017

Immunity

CD4⁺ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

21-11-2017

Lancet (London, England)

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial.

18-11-2017

International journal of radiation oncology, biology, physics

Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma: Influence of Gonadal Hormone Exposure.

15-11-2017

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma.

15-11-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Selected Alkylating Agents Can Overcome Drug Tolerance of G₀-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

15-11-2017

BMJ open

Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study.

14-11-2017

F1000Research

Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data.

11-11-2017

Journal of molecular biology

Regulation of USP7: A High Incidence of E3 Complexes.

10-11-2017

Swiss medical weekly

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue.

10-11-2017

Cell host & microbe

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

08-11-2017

Oncotarget

The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

07-11-2017

Oncotarget

The methylated way to translation.

07-11-2017

Breast cancer research : BCR

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.

07-11-2017

The Journal of cell biology

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

06-11-2017

High-throughput

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.

06-11-2017

Nature

Association analysis identifies 65 new breast cancer risk loci.

02-11-2017

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20).

01-11-2017

Urology

Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

01-11-2017

Breast cancer research and treatment

Pharmaceutically treated anxiety but not depression prior to cancer diagnosis predicts the onset of cardiovascular disease among breast cancer survivors.

01-11-2017

European journal of cancer (Oxford, England : 1990)

Elderly patients with gastrointestinal stromal tumour (GIST) receive less treatment irrespective of performance score or comorbidity - A retrospective multicentre study in a large cohort of GIST patients.

01-11-2017

International journal of cancer

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.

01-11-2017

JCO precision oncology

Profound Immunotherapy Response in Mismatch Repair-Deficient Breast Cancer.

01-11-2017

Abdominal radiology (New York)

Whole-volume vs. segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases.

01-11-2017

The Journal of antimicrobial chemotherapy

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

01-11-2017

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Patient-reported (EORTC QLQ-CIPN20) versus physician-reported (CTCAE) quantification of oxaliplatin- and paclitaxel/carboplatin-induced peripheral neuropathy in NCCTG/Alliance clinical trials.

01-11-2017

Breast cancer research and treatment

The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study.

01-11-2017

Advances in anatomic pathology

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.

01-11-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER⁺/HER2^- Breast Cancer.

01-11-2017

Archives of physical medicine and rehabilitation

Validation and Refinement of Prediction Models to Estimate Exercise Capacity in Cancer Survivors Using the Steep Ramp Test.

01-11-2017

Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.

Surveillance of Dutch Patients With Li-Fraumeni Syndrome: The LiFe-Guard Study.

Definitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity.

Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry.

In vivo veritas: Finding novel genes involved in liver cancer through in vivo genetic screens.

BRCA1-like profile is not significantly associated with survival benefit of non-myeloablative intensified chemotherapy in the GAIN randomized controlled trial.

Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.

Assessing and comparing the quality of wound centres: a literature review and benchmarking pilot.

Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy.

In Reply: Centralization of Upper Gastrointestinal Cancer Care Should Be Dictated by Quality of Care.

Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery.

Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure.

Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.

Targeting immune checkpoints in breast cancer: an update of early results.

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.

CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial.

Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma: Influence of Gonadal Hormone Exposure.

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma.

Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study.

Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data.

Regulation of USP7: A High Incidence of E3 Complexes.

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue.

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

The methylated way to translation.

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.

Association analysis identifies 65 new breast cancer risk loci.

Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20).

Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

Pharmaceutically treated anxiety but not depression prior to cancer diagnosis predicts the onset of cardiovascular disease among breast cancer survivors.

Elderly patients with gastrointestinal stromal tumour (GIST) receive less treatment irrespective of performance score or comorbidity - A retrospective multicentre study in a large cohort of GIST patients.

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.

Profound Immunotherapy Response in Mismatch Repair-Deficient Breast Cancer.

Whole-volume vs. segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases.

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

Patient-reported (EORTC QLQ-CIPN20) versus physician-reported (CTCAE) quantification of oxaliplatin- and paclitaxel/carboplatin-induced peripheral neuropathy in NCCTG/Alliance clinical trials.

The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study.

Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER+/HER2- Breast Cancer.

Validation and Refinement of Prediction Models to Estimate Exercise Capacity in Cancer Survivors Using the Steep Ramp Test.

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Human mass balance study and metabolite profiling of ¹⁴C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.

CD4⁺ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

Selected Alkylating Agents Can Overcome Drug Tolerance of G₀-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER⁺/HER2^- Breast Cancer.