Publications

Genes & development

Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei.

01-12-1997

The Biochemical journal

The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.

01-12-1997

The Journal of clinical investigation

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

15-11-1997

Patient education and counseling

Genetic counseling for hereditary cancer: a pilot study on experiences of patients and family members.

14-11-1997

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

14-11-1997

The Journal of biological chemistry

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.

07-11-1997

The Journal of cell biology

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

03-11-1997

Acta oto-laryngologica

Development and clinical evaluation of a second-generation voice prosthesis (Provox 2), designed for anterograde and retrograde insertion.

01-11-1997

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997

The Journal of experimental medicine

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.

20-10-1997

The EMBO journal

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

01-10-1997

The Journal of biological chemistry

CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition.

26-09-1997

Oncogene

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.

04-09-1997

Oncogene

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

01-09-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

Oncogene

Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.

18-08-1997

Journal of chromatography. B, Biomedical sciences and applications

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

15-08-1997

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

01-08-1997

Seminars in oncology

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

01-08-1997

Blood

Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules.

01-08-1997

Stroke

Assessing quality of life after stroke. The value and limitations of proxy ratings.

01-08-1997

Journal of cell science

A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells.

01-08-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Successful intraperitoneal suramin treatment of peritoneal mesothelioma.

01-08-1997

Acta crystallographica. Section D, Biological crystallography

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

01-07-1997

Biochemical and biophysical research communications

The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences.

27-06-1997

FEBS letters

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.

23-06-1997

Trends in genetics : TIG

Genetic dissection of the function of mammalian P-glycoproteins.

01-06-1997

Seminars in cancer biology

The physiological function of drug-transporting P-glycoproteins.

01-06-1997

Oncogene

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

29-05-1997

The Biochemical journal

Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin.

15-05-1997

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.

01-05-1997

Nucleic acids research

Cre-mediated somatic site-specific recombination in mice.

01-05-1997

Medical care

The use of significant others as proxy raters of the quality of life of patients with brain cancer.

01-05-1997

Proceedings of the National Academy of Sciences of the United States of America

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

15-04-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer.

01-04-1997

Laboratory investigation; a journal of technical methods and pathology

The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.

01-04-1997

Molecular biology of the cell

Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.

01-04-1997

The Journal of cell biology

The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit.

24-03-1997

Proceedings of the National Academy of Sciences of the United States of America

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.

18-03-1997

Oncogene

Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.

06-03-1997

Proceedings of the National Academy of Sciences of the United States of America

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

04-03-1997

Cancer treatment reviews

Alternative formulations of paclitaxel.

01-03-1997

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Value of caregiver ratings in evaluating the quality of life of patients with cancer.

01-03-1997

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur.

01-03-1997

Cancer treatment reviews

Growth factors in human ovarian cancer.

01-03-1997

Behring Institute Mitteilungen

Mechanisms of antigenic variation in African trypanosomes.

01-03-1997

Cell

CDK-independent activation of estrogen receptor by cyclin D1.

07-02-1997

The EMBO journal

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.

03-02-1997

Seminars in oncology

Carboplatin and paclitaxel in patients with advanced ovarian cancer: a dose-finding study.

01-02-1997

Genes & development

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

15-01-1997