Publications

Experimental lung research

Genetics of quantitative and qualitative aspects of lung tumorigenesis in the mouse: multiple interacting Susceptibility to lung cancer (Sluc) genes with large effects.

11-07-1998

Oncogene

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.

09-07-1998

Molecular and biochemical parasitology

The modified DNA base beta-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei.

01-07-1998

European journal of immunology

The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

01-07-1998

European journal of cancer (Oxford, England : 1990)

Quality of life assessment in daily clinical oncology practice: a feasibility study.

01-07-1998

Journal of clinical epidemiology

Comparison of patient and proxy EORTC QLQ-C30 ratings in assessing the quality of life of cancer patients.

01-07-1998

Blood

The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils.

15-06-1998

Journal of chromatography. B, Biomedical sciences and applications

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.

12-06-1998

Genes & development

p107 is a suppressor of retinoblastoma development in pRb-deficient mice.

01-06-1998

Electrophoresis

High performance density gradient electrophoresis of subcellular organelles, protein complexes and proteins.

01-06-1998

Journal of cell science

Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes.

01-06-1998

Anti-cancer drugs

Continuous infusion of low-dose topotecan: pharmacokinetics and pharmacodynamics during a phase II study in patients with small cell lung cancer.

01-06-1998

Pharmacological research

The pharmacological role of P-glycoprotein in the intestinal epithelium.

01-06-1998

Cancer research

Comparative pharmacology of the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats, and humans.

01-06-1998

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis.

01-06-1998

Molecular and cellular biology

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

01-06-1998

Molecular and biochemical parasitology

Changes in expression site control and DNA modification in Trypanosoma brucei during differentiation of the bloodstream form to the procyclic form.

15-05-1998

Journal of chromatography. B, Biomedical sciences and applications

Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.

08-05-1998

Analytical biochemistry

The modified DNA base beta-D-glucosylhydroxymethyluracil confers resistance to micrococcal nuclease and is incompletely recovered by 32P-postlabeling.

01-05-1998

Genes & development

Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.

15-04-1998

Cancer chemotherapy and pharmacology

A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study.

02-04-1998

Annals of oncology : official journal of the European Society for Medical Oncology

Malignant effusions contain lysophosphatidic acid (LPA)-like activity.

01-04-1998

The EMBO journal

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.

01-04-1998

The Journal of clinical investigation

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

01-04-1998

The Journal of biological chemistry

CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

27-03-1998

Current biology : CB

Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways.

26-03-1998

The Journal of cell biology

Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src.

09-03-1998

Proceedings of the National Academy of Sciences of the United States of America

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

03-03-1998

Cell adhesion and communication

Glomerular extracellular matrix components and integrins.

01-03-1998

Molecular and biochemical parasitology

Control of VSG gene expression sites in Trypanosoma brucei.

01-03-1998

Cancer treatment reviews

Cisplatin resistance and DNA repair.

18-02-1998

Journal of the National Cancer Institute

Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy.

04-02-1998

Nederlands tijdschrift voor geneeskunde

[Last word on hormone replacement and breast cancer?].

17-01-1998

European journal of cancer (Oxford, England : 1990)

Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.

01-01-1998

Pharmacological research

Clinical research on antiangiogenic therapy.

01-01-1998

Methods in molecular medicine

Saturating mutagenesis and characterization of a herpesvirus genome using in vivo reconstitution of virus from cloned subgenomic regions.

01-01-1998

Cellular and molecular life sciences : CMLS

Functional analysis of mouse Polycomb group genes.

01-01-1998

International journal of clinical pharmacology and therapeutics

Pharmacological insights from P-glycoprotein knockout mice.

01-01-1998

Biochimica et biophysica acta

E2F: a nodal point in cell cycle regulation.

09-12-1997

The Biochemical journal

The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.

01-12-1997

Developmental dynamics : an official publication of the American Association of Anatomists

Spatial and temporal expression of the beta1D integrin during mouse development.

01-12-1997

Molecular and biochemical parasitology

beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

01-12-1997

Genes & development

Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei.

01-12-1997

The Journal of clinical investigation

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

15-11-1997

Patient education and counseling

Genetic counseling for hereditary cancer: a pilot study on experiences of patients and family members.

14-11-1997

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

14-11-1997

The Journal of biological chemistry

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.

07-11-1997

The Journal of cell biology

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

03-11-1997

Acta oto-laryngologica

Development and clinical evaluation of a second-generation voice prosthesis (Provox 2), designed for anterograde and retrograde insertion.

01-11-1997

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997