Publications

Molecular cancer therapeutics

OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.

01-02-2014

Current opinion in genetics & development

Finding effective cancer therapies through loss of function genetic screens.

01-02-2014

EMBO reports

RBR E3-ligases at work.

01-02-2014

Breast cancer research and treatment

Long-term impact of the 70-gene signature on breast cancer outcome.

01-02-2014

Clinical cancer research : an official journal of the American Association for Cancer Research

Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?

01-02-2014

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

NAD⁺ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study.

01-02-2014

Journal of medical genetics

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.

01-02-2014

EMBO molecular medicine

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

01-02-2014

Breast cancer research and treatment

Mammographic screening detects low-risk tumor biology breast cancers.

01-02-2014

Annals of surgical oncology

Reply to "Anti-cytokeratin CAM5.2 recognized CK8 mainly, but not CK18: comment on 'Early assessment of axillary response with 18F-FDG PET/CT during neoadjuvant chemotherapy in stage II-III breast cancer: implications for surgical management of the axilla. Ann Surg Oncol. 2013;20(7):2227-35'".

01-02-2014

Nature reviews. Urology

Urological complications after treatment of cervical cancer.

01-02-2014

European journal of radiology

Avoiding preoperative breast MRI when conventional imaging is sufficient to stage patients eligible for breast conserving therapy.

01-02-2014

Cell death and differentiation

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential.

01-02-2014

Breast cancer research and treatment

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care.

01-02-2014

Breast (Edinburgh, Scotland)

Time trends and inter-hospital variation in treatment and axillary staging of patients with ductal carcinoma in situ of the breast in the era of screening in Southern Netherlands.

01-02-2014

World journal of urology

Do targeted agents offer clinical benefit as presurgical therapy?

01-02-2014

Nederlands tijdschrift voor geneeskunde

[Biobanks and the return of results to donors].

30-01-2014

Oncogene

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.

30-01-2014

BMC cancer

The Nightingale study: rationale, study design and baseline characteristics of a prospective cohort study on shift work and breast cancer risk among nurses.

29-01-2014

Scientific reports

The fidelity of stochastic single-molecule super-resolution reconstructions critically depends upon robust background estimation.

24-01-2014

Journal of immunology (Baltimore, Md. : 1950)

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.

15-01-2014

PloS one

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101).

15-01-2014

BMC cancer

The efficacy of a standardized questionnaire in facilitating personalized communication about problems encountered in cancer genetic counseling: design of a randomized controlled trial.

15-01-2014

Frontiers in genetics

Current composite-feature classification methods do not outperform simple single-genes classifiers in breast cancer prognosis.

07-01-2014

International journal of radiation oncology, biology, physics

Alpha/beta ratio for normal lung tissue as estimated from lung cancer patients treated with stereotactic body and conventionally fractionated radiation therapy.

01-01-2014

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Gastric cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

01-01-2014

Urologic oncology

Ensuring comprehensive assessment of urinary problems in prostate cancer through patient-physician concordance.

01-01-2014

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Additional weekly Cetuximab to concurrent chemoradiotherapy in locally advanced non-small cell lung carcinoma: efficacy and safety outcomes of a randomized, multi-center phase II study investigating.

01-01-2014

Acta oncologica (Stockholm, Sweden)

Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia.

01-01-2014

Health technology assessment (Winchester, England)

The clinical effectiveness and cost-effectiveness of ablative therapies in the management of liver metastases: systematic review and economic evaluation.

01-01-2014

Journal of pharmaceutical and biomedical analysis

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma.

01-01-2014

The Journal of investigative dermatology

Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.

01-01-2014

Immunological reviews

TCR repertoires of intratumoral T-cell subsets.

01-01-2014

European journal of nuclear medicine and molecular imaging

Sequential (18)F-FDG PET/CT for early prediction of complete pathological response in breast and axilla during neoadjuvant chemotherapy.

01-01-2014

Oral oncology

The influence of nodal yield in neck dissections on lymph node ratio in head and neck cancer.

01-01-2014

Nature genetics

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

01-01-2014

Urology

Induction chemotherapy followed by surgery in node positive bladder cancer.

01-01-2014

BMC cancer

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.

28-12-2013

Cell reports

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

26-12-2013

OncoTargets and therapy

Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity.

19-12-2013

Translational psychiatry

dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

17-12-2013

British journal of cancer

Neoadjuvant chemotherapy adaptation and serial MRI response monitoring in ER-positive HER2-negative breast cancer.

10-12-2013

Nature communications

Ribosome profiling reveals features of normal and disease-associated mitochondrial translation.

05-12-2013

Annals of surgical oncology

Selection of patients for hepatic surgery of colorectal cancer liver metastasis based on genomic aberrations.

01-12-2013

Brain imaging and behavior

Functional MRI studies in non-CNS cancers.

01-12-2013

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Motion compensated digital tomosynthesis.

01-12-2013

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Adaptive radiotherapy with an average anatomy model: evaluation and quantification of residual deformations in head and neck cancer patients.

01-12-2013

Biochimica et biophysica acta

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.

01-12-2013

Current opinion in pharmacology

Genetically modified mouse models for oral drug absorption and disposition.

01-12-2013

Brain imaging and behavior

Chemotherapy-related cognitive dysfunction: current animal studies and future directions.

01-12-2013