Publications

Cell reports

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.

24-08-2021

Cancers

Deterioration of Intended Target Volume Radiation Dose Due to Anatomical Changes in Patients with Head-and-Neck Cancer.

24-08-2021

Nature communications

Detection and characterization of lung cancer using cell-free DNA fragmentomes.

20-08-2021

Breast cancer research : BCR

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment.

18-08-2021

Oncotarget

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing.

17-08-2021

EJNMMI research

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors.

16-08-2021

Cancer research

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

15-08-2021

Cancer

Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities.

15-08-2021

Cancer cell

Developing and validating model systems for immuno-oncology.

09-08-2021

Cancers

Preferences of Treatment Strategies among Women with Low-Risk DCIS and Oncologists.

06-08-2021

Cell stem cell

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

05-08-2021

Molecular cell

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

05-08-2021

Cold Spring Harbor perspectives in biology

Formation of Tissue-Resident CD8⁺ T-Cell Memory.

02-08-2021

Annals of oncology : official journal of the European Society for Medical Oncology

'IMpassionate conflicts' in immunotherapy trials for metastatic triple-negative breast cancer.

01-08-2021

Cancer reports (Hoboken, N.J.)

ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastatic castration-resistant prostate cancer patients: A phase Ib study.

01-08-2021

The breast journal

Randomized controlled trial comparing magnetic marker localization (MaMaLoc) with wire-guided localization in the treatment of early-stage breast cancer.

01-08-2021

European radiology

Introducing the Node Reporting and Data System 1.0 (Node-RADS): a concept for standardized assessment of lymph nodes in cancer.

01-08-2021

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The first-in-human implementation of adaptive 4D cone beam CT for lung cancer radiotherapy: 4DCBCT in less time with less dose.

01-08-2021

The Journal of urology

Safety and Efficacy of Atezolizumab in Understudied Populations with Pretreated Urinary Tract Carcinoma: Subgroup Analyses of the SAUL Study in Real-World Practice.

01-08-2021

Clinical oncology (Royal College of Radiologists (Great Britain))

Beyond Teenage and Young Adult Cancer Care: Care Experiences of Patients Aged 25-39 Years Old in the UK National Health Service.

01-08-2021

Trends in cell biology

REV7: Jack of many trades.

01-08-2021

JNCI cancer spectrum

Colorectal Cancer Care and Patients' Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves.

01-08-2021

Acta crystallographica. Section D, Structural biology

CCD²: design constructs for protein expression, the easy way.

01-08-2021

Molecular oncology

Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention.

01-08-2021

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Peroperative scoring systems for predicting the outcome of cytoreductive surgery in advanced-stage ovarian cancer - A systematic review.

01-08-2021

European journal of radiology

Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone.

01-08-2021

Nature

Genetic insights into biological mechanisms governing human ovarian ageing.

01-08-2021

ESMO open

The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II.

01-08-2021

Cancer immunology, immunotherapy : CII

T-VEC for stage IIIB-IVM1a melanoma achieves high rates of complete and durable responses and is associated with tumor load: a clinical prediction model.

01-08-2021

Journal for immunotherapy of cancer

HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial.

01-08-2021

British journal of clinical pharmacology

Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.

01-08-2021

EBioMedicine

Postoperative circulating tumour DNA is associated with pathologic response and recurrence-free survival after resection of colorectal cancer liver metastases.

01-08-2021

Breast cancer research and treatment

Letter to the editor regarding: 'Association between BRCA mutational status and survival in patients with breast cancer: a systematic review and meta-analysis'.

01-08-2021

Journal of adolescent and young adult oncology

Lessons for Employing Participatory Design When Developing Care for Young People with Cancer: A Qualitative Multiple-Case Study.

01-08-2021

Nature reviews. Clinical oncology

Precision oncology in metastatic colorectal cancer - from biology to medicine.

01-08-2021

Neurourology and urodynamics

Individual risk prediction of urinary incontinence after prostatectomy and impact on treatment choice in patients with localized prostate cancer.

01-08-2021

European urology oncology

Real-world Outcomes of Sequential Androgen-receptor Targeting Therapies with or Without Interposed Life-prolonging Drugs in Metastatic Castration-resistant Prostate Cancer: Results from the Dutch Castration-resistant Prostate Cancer Registry.

01-08-2021

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Reaction on the Interpretation of the Hippocampus Avoidance Prophylactic Cranial Irradiation Trial in SCLC (NCT01780675).

01-08-2021

European journal of cancer (Oxford, England : 1990)

Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group.

01-08-2021

Cancer discovery

Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.

01-08-2021

JAMA surgery

Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases: A Phase 2 Randomized Clinical Trial.

01-08-2021

Histopathology

High CD8⁺ tumour-infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.

01-08-2021

Annals of surgery

Neoadjuvant Cytoreductive Treatment With BRAF/MEK Inhibition of Prior Unresectable Regionally Advanced Melanoma to Allow Complete Surgical Resection, REDUCTOR: A Prospective, Single-arm, Open-label Phase II Trial.

01-08-2021

Breast cancer research and treatment

Pathologic response of ductal carcinoma in situ to neoadjuvant systemic treatment in HER2-positive breast cancer.

01-08-2021

Medical decision making : an international journal of the Society for Medical Decision Making

Modeling Diagnostic Strategies to Manage Toxic Adverse Events following Cancer Immunotherapy.

01-08-2021

Cell reports

The Cancer SENESCopedia: A delineation of cancer cell senescence.

27-07-2021

Cancers

Effects of and Lessons Learned from an Internet-Based Physical Activity Support Program (with and without Physiotherapist Telephone Counselling) on Physical Activity Levels of Breast and Prostate Cancer Survivors: The PABLO Randomized Controlled Trial.

21-07-2021

Biochemistry

The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam.

20-07-2021

Cancers

PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.

18-07-2021

Nature communications

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.

16-07-2021

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.

Deterioration of Intended Target Volume Radiation Dose Due to Anatomical Changes in Patients with Head-and-Neck Cancer.

Detection and characterization of lung cancer using cell-free DNA fragmentomes.

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment.

Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing.

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors.

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities.

Developing and validating model systems for immuno-oncology.

Preferences of Treatment Strategies among Women with Low-Risk DCIS and Oncologists.

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

Formation of Tissue-Resident CD8+ T-Cell Memory.

'IMpassionate conflicts' in immunotherapy trials for metastatic triple-negative breast cancer.

ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastatic castration-resistant prostate cancer patients: A phase Ib study.

Randomized controlled trial comparing magnetic marker localization (MaMaLoc) with wire-guided localization in the treatment of early-stage breast cancer.

Introducing the Node Reporting and Data System 1.0 (Node-RADS): a concept for standardized assessment of lymph nodes in cancer.

The first-in-human implementation of adaptive 4D cone beam CT for lung cancer radiotherapy: 4DCBCT in less time with less dose.

Safety and Efficacy of Atezolizumab in Understudied Populations with Pretreated Urinary Tract Carcinoma: Subgroup Analyses of the SAUL Study in Real-World Practice.

Beyond Teenage and Young Adult Cancer Care: Care Experiences of Patients Aged 25-39 Years Old in the UK National Health Service.

REV7: Jack of many trades.

Colorectal Cancer Care and Patients' Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves.

CCD2: design constructs for protein expression, the easy way.

Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention.

Peroperative scoring systems for predicting the outcome of cytoreductive surgery in advanced-stage ovarian cancer - A systematic review.

Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone.

Genetic insights into biological mechanisms governing human ovarian ageing.

The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II.

T-VEC for stage IIIB-IVM1a melanoma achieves high rates of complete and durable responses and is associated with tumor load: a clinical prediction model.

HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial.

Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.

Postoperative circulating tumour DNA is associated with pathologic response and recurrence-free survival after resection of colorectal cancer liver metastases.

Letter to the editor regarding: 'Association between BRCA mutational status and survival in patients with breast cancer: a systematic review and meta-analysis'.

Lessons for Employing Participatory Design When Developing Care for Young People with Cancer: A Qualitative Multiple-Case Study.

Precision oncology in metastatic colorectal cancer - from biology to medicine.

Individual risk prediction of urinary incontinence after prostatectomy and impact on treatment choice in patients with localized prostate cancer.

Real-world Outcomes of Sequential Androgen-receptor Targeting Therapies with or Without Interposed Life-prolonging Drugs in Metastatic Castration-resistant Prostate Cancer: Results from the Dutch Castration-resistant Prostate Cancer Registry.

Reaction on the Interpretation of the Hippocampus Avoidance Prophylactic Cranial Irradiation Trial in SCLC (NCT01780675).

Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group.

Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.

Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases: A Phase 2 Randomized Clinical Trial.

High CD8+ tumour-infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.

Neoadjuvant Cytoreductive Treatment With BRAF/MEK Inhibition of Prior Unresectable Regionally Advanced Melanoma to Allow Complete Surgical Resection, REDUCTOR: A Prospective, Single-arm, Open-label Phase II Trial.

Pathologic response of ductal carcinoma in situ to neoadjuvant systemic treatment in HER2-positive breast cancer.

Modeling Diagnostic Strategies to Manage Toxic Adverse Events following Cancer Immunotherapy.

The Cancer SENESCopedia: A delineation of cancer cell senescence.

Effects of and Lessons Learned from an Internet-Based Physical Activity Support Program (with and without Physiotherapist Telephone Counselling) on Physical Activity Levels of Breast and Prostate Cancer Survivors: The PABLO Randomized Controlled Trial.

The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam.

PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.

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A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors.

Formation of Tissue-Resident CD8⁺ T-Cell Memory.

CCD²: design constructs for protein expression, the easy way.

High CD8⁺ tumour-infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.