Publications

British journal of clinical pharmacology

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function.

01-08-2015

Genes & development

Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis.

01-08-2015

Breast cancer research and treatment

The prognostic value of the neoadjuvant response index in triple-negative breast cancer: validation and comparison with pathological complete response as outcome measure.

01-08-2015

European urology

Reply to Eliezer M. Van Allen, Levi A. Garraway and Jonathan E. Rosenberg's Letter to the Editor re: Floris H. Groenendijk, Jeroen de Jong, Elisabeth E. Fransen van de Putte, et al. ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2015.01.014.

01-08-2015

The Lancet. Oncology

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.

01-08-2015

Nature reviews. Cancer

Evolving synergistic combinations of targeted immunotherapies to combat cancer.

01-08-2015

Breast (Edinburgh, Scotland)

Early stage cost-effectiveness analysis of a BRCA1-like test to detect triple negative breast cancers responsive to high dose alkylating chemotherapy.

01-08-2015

The international journal of biochemistry & cell biology

Exposure to arginine analog canavanine induces aberrant mitochondrial translation products, mitoribosome stalling, and instability of the mitochondrial proteome.

01-08-2015

Clinical pharmacokinetics

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

01-08-2015

Biochimica et biophysica acta

C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake.

01-08-2015

European urology

Re: Alessandro Volpe, Kamran Ahmed, Prokar Dasgupta, et al. Pilot Validation Study of the European Association of Urology Robotic Training Curriculum. Eur Urol 2015;68:292-9.

01-08-2015

Molecular oncology

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

01-08-2015

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Plasma membrane targeting by short chain sphingolipids inserted in liposomes improves anti-tumor activity of mitoxantrone in an orthotopic breast carcinoma xenograft model.

01-08-2015

Trends in biochemical sciences

Layers of DUB regulation.

01-08-2015

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Tumour delineation in oesophageal cancer - A prospective study of delineation in PET and CT with and without endoscopically placed clip markers.

01-08-2015

European journal of cancer (Oxford, England : 1990)

Feasibility of a prospective, randomised, open-label, international multicentre, phase III, non-inferiority trial to assess the safety of active surveillance for low risk ductal carcinoma in situ - The LORD study.

01-08-2015

Breast cancer research and treatment

Fat/water ratios measured with diffuse reflectance spectroscopy to detect breast tumor boundaries.

01-08-2015

Lancet (London, England)

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial.

01-08-2015

Clinical breast cancer

Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective.

01-08-2015

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Radiation-induced dose-dependent changes of the spleen following postoperative chemoradiotherapy for gastric cancer.

01-08-2015

Dysphagia

Effects of Strengthening Exercises on Swallowing Musculature and Function in Senior Healthy Subjects: a Prospective Effectiveness and Feasibility Study.

01-08-2015

Radiation oncology (London, England)

Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer.

30-07-2015

Health and quality of life outcomes

Validation of the French translation-adaptation of the impact of cancer questionnaire version 2 (IOCv2) in a breast cancer survivor population.

29-07-2015

British journal of cancer

Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.

28-07-2015

British journal of cancer

Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?

28-07-2015

Science translational medicine

Optimizing sharing of hospital biobank samples.

22-07-2015

International journal of clinical and experimental pathology

Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.

21-07-2015

Ecancermedicalscience

Staff perceptions of change resulting from participation in a European cancer accreditation programme: a snapshot from eight cancer centres.

17-07-2015

Genes & development

Origins, genetic landscape, and emerging therapies of small cell lung cancer.

15-07-2015

PloS one

Co-Orientation: Quantifying Simultaneous Co-Localization and Orientational Alignment of Filaments in Light Microscopy.

15-07-2015

Cancer cell

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy.

13-07-2015

eLife

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

11-07-2015

PloS one

Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression.

07-07-2015

Proceedings of the National Academy of Sciences of the United States of America

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

07-07-2015

PloS one

Studying Hospitalizations and Mortality in the Netherlands: Feasible and Valid Using Two-Step Medical Record Linkage with Nationwide Registers.

07-07-2015

Journal of proteome research

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

02-07-2015

American journal of human genetics

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.

02-07-2015

Nature

The core spliceosome as target and effector of non-canonical ATM signalling.

02-07-2015

BMC medicine

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.

02-07-2015

The New England journal of medicine

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

02-07-2015

Pharmaceutical research

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).

01-07-2015

European journal of cancer (Oxford, England : 1990)

Treatment-related differences in health related quality of life and disease specific symptoms among colon cancer survivors: results from the population-based PROFILES registry.

01-07-2015

Cancer research

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

01-07-2015

Clinical lung cancer

Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy.

01-07-2015

Trends in immunology

Assessing T lymphocyte function and differentiation by genetically encoded reporter systems.

01-07-2015

CPT: pharmacometrics & systems pharmacology

Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin.

01-07-2015

The British journal of nutrition

Dietary changes and dietary supplement use, and underlying motives for these habits reported by colorectal cancer survivors of the Patient Reported Outcomes Following Initial Treatment and Long-Term Evaluation of Survivorship (PROFILES) registry.

01-07-2015

EBioMedicine

Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer.

01-07-2015

The lancet. Psychiatry

Patient-reported depression measures in cancer: a meta-review.

01-07-2015

Gene therapy

Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines.

01-07-2015