Publications

Folding & design

Evolution of immunoglobulin-like modules in chitinases: their structural flexibility and functional implications.

01-01-1997

Cancer chemotherapy and pharmacology

The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue.

01-01-1997

British journal of cancer

Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.

01-01-1997

British journal of cancer

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

01-01-1997

Critical reviews in oncogenesis

The Cbl family of signal transduction molecules.

01-01-1997

Cancer chemotherapy and pharmacology

Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.

01-01-1997

Journal of cell science

The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit.

01-01-1997

European journal of haematology

Ultrastructural localization of Charcot-Leyden crystal protein in human eosinophils and basophils.

01-01-1997

Journal of virology

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.

01-01-1997

The EMBO journal

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

16-12-1996

Journal of the National Cancer Institute

Induced abortion and risk for breast cancer: reporting (recall) bias in a Dutch case-control study.

04-12-1996

The Netherlands journal of medicine

Tamoxifen, balancing risks and benefits.

01-12-1996

Genes & development

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

01-12-1996

Nature genetics

Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse.

01-12-1996

American journal of epidemiology

p53 protein overexpression in relation to risk factors for breast cancer.

15-11-1996

The EMBO journal

Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans.

15-11-1996

British journal of pharmacology

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.

01-11-1996

The Journal of experimental medicine

Domains of the TCR beta-chain required for early thymocyte development.

01-11-1996

Journal of pharmaceutical sciences

Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244).

01-11-1996

The Journal of cell biology

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

01-11-1996

Journal of pharmaceutical and biomedical analysis

The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.

01-11-1996

The Journal of biological chemistry

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.

18-10-1996

The Journal of neuroscience : the official journal of the Society for Neuroscience

Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene.

15-10-1996

Pharmacy world & science : PWS

Etoposide phosphate, the water soluble prodrug of etoposide.

01-10-1996

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study.

01-10-1996

European journal of biochemistry

The role of the cytoplasmic domain of alpha 6 integrin in the assembly and function of alpha 6 beta 1 and alpha 6 beta 4.

01-10-1996

Current opinion in cell biology

Hemidesmosomes: roles in adhesion, signaling and human diseases.

01-10-1996

Seminars in cancer biology

Complementation tagging of cooperating oncogenes in knockout mice.

01-10-1996

The Journal of biological chemistry

Assembled pre-B cell receptor complexes are retained in the endoplasmic reticulum by a mechanism that is not selective for the pseudo-light chain.

09-08-1996

Clinical pharmacokinetics

Clinical pharmacokinetics of topotecan.

01-08-1996

European journal of cancer (Oxford, England : 1990)

The toxicity of radiotherapy following high-dose chemotherapy with peripheral blood stem cell support in high-risk breast cancer: a preliminary analysis.

01-08-1996

The Journal of experimental medicine

CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development.

01-08-1996

Mechanisms of development

The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.

01-08-1996

Oncogene

Formation of Shc/Grb2- and Crk adaptor complexes containing tyrosine phosphorylated Cbl upon stimulation of the B-cell antigen receptor.

18-07-1996

Journal of the National Cancer Institute

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.

17-07-1996

Journal of cell science

Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties.

01-07-1996

Cell adhesion and communication

Genomic organization of the mouse beta 1 gene: conservation of the beta 1D but not of the beta 1B and beta 1C integrin splice variants.

01-07-1996

Nature genetics

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice.

01-07-1996

Nucleic acids research

The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands.

01-07-1996

Journal of chromatography. B, Biomedical applications

Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography.

07-06-1996

Biochimica et biophysica acta

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins.

07-06-1996

European journal of cancer (Oxford, England : 1990)

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

01-06-1996

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Palliative effect of metaiodobenzylguanidine in metastatic carcinoid tumors.

01-06-1996

The Journal of clinical investigation

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

01-06-1996

Drug metabolism and disposition: the biological fate of chemicals

Isolation, purification and biological activity of major docetaxel metabolites from human feces.

01-06-1996

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

A study of the reliability, validity and responsiveness of the HIV overview of problems evaluation system (HOPES) in assessing the quality of life of patients with AIDS and symptomatic HIV infection.

01-06-1996

Oncogene

Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.

16-05-1996

Biochimica et biophysica acta

Retroviral insertional mutagenesis as a strategy to identify cancer genes.

16-05-1996

The EMBO journal

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

15-05-1996

British journal of cancer

Efficacy of up-front 5-fluorouracil-epidoxorubicin-cyclophosphamide (FEC) chemotherapy with an increased dose of epidoxorubicin in high-risk breast cancer patients.

01-05-1996