Publications

Cancer chemotherapy and pharmacology

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.

01-05-2020

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

01-04-2020

Clinical pharmacokinetics

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation.

01-04-2020

Journal of geriatric oncology

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials.

01-04-2020

Journal of pharmaceutical and biomedical analysis

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma.

20-03-2020

Journal of clinical pharmacology

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development.

01-03-2020

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Use of leftovers of monoclonal antibody products after partial extraction - A microbiological safety study.

01-03-2020

The AAPS journal

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry.

06-02-2020

European journal of drug metabolism and pharmacokinetics

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.

01-02-2020

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors.

01-02-2020

Clinical pharmacokinetics

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.

01-02-2020

British journal of clinical pharmacology

Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen.

01-01-2020

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children.

01-01-2020

Pharmaceutical research

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation.

26-12-2019

Pharmacotherapy

Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer.

01-12-2019

CPT: pharmacometrics & systems pharmacology

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.

01-12-2019

Pharmaceutical research

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.

15-11-2019

Analytica chimica acta

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial.

08-11-2019

Pharmaceutical research

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

15-10-2019

Therapeutic drug monitoring

Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study.

01-10-2019

Clinical pharmacokinetics

Predictive Value of Microdose Pharmacokinetics.

01-10-2019

British journal of clinical pharmacology

Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model.

01-10-2019

Therapeutic drug monitoring

Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry.

01-10-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir.

15-09-2019

Journal of pharmaceutical and biomedical analysis

Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma.

10-09-2019

European journal of clinical pharmacology

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine.

01-09-2019

Cancer chemotherapy and pharmacology

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.

01-09-2019

Acta psychiatrica Scandinavica

Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort).

01-09-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium.

01-09-2019

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence.

01-08-2019

British journal of clinical pharmacology

Exposure-response modeling of tocilizumab in rheumatoid arthritis using continuous composite measures and their individual components.

01-08-2019

Blood advances

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes.

23-07-2019

Neonatology

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.

01-07-2019

Bone marrow transplantation

Tyrosine kinase inhibitor levels matter in treating chronic GVHD.

01-07-2019

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Pharmacological Considerations in Antithymocyte Globulin Exposure Calculation.

01-06-2019

BMC cancer

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy versus palliative systemic chemotherapy in stomach cancer patients with peritoneal dissemination, the study protocol of a multicentre randomised controlled trial (PERISCOPE II).

06-05-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients.

01-05-2019

Breast cancer research and treatment

Tamoxifen and pregnancy: an absolute contraindication?

01-05-2019

Clinical pharmacokinetics

Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients.

01-05-2019

Clinical pharmacokinetics

Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation.

01-05-2019

Digestion

Does the 5-Aminosalicylate Concentration Correlate with the Efficacy of Oral 5-Aminosalicylate and Predict Response in Patients with Inflammatory Bowel Disease? A Systematic Review.

24-04-2019

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Innate Immune Recovery Predicts CD4⁺ T Cell Reconstitution after Hematopoietic Cell Transplantation.

01-04-2019

Drugs & aging

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice.

01-04-2019

Journal of translational autoimmunity

Quantification of neutralizing anti-drug antibodies and their neutralizing capacity using competitive displacement and tandem mass spectrometry: Infliximab as proof of principle.

01-04-2019

Cancer medicine

Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort.

01-04-2019

Clinical genitourinary cancer

Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer Undergoing Hemodialysis.

01-04-2019

Prostate cancer and prostatic diseases

Impact of age on exposure to oral antiandrogen therapies in clinical practice.

01-03-2019

Clinical pharmacokinetics

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology.

01-03-2019

PloS one

Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.

15-02-2019

Pharmaceutical research

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

07-01-2019