Publications

Nature methods

shRNA libraries and their use in cancer genetics.

01-09-2006

The Journal of biological chemistry

A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.

04-08-2006

Nature cell biology

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

01-08-2006

The British journal of dermatology

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

01-07-2006

Proceedings of the National Academy of Sciences of the United States of America

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle.

04-04-2006

Nature chemical biology

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

01-04-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

Methods in enzymology

Functional annotation of deubiquitinating enzymes using RNA interference.

09-11-2005

Nature cell biology

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene.

01-11-2005

Cell

The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

23-09-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Cell

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

17-06-2005

Cancer cell

A functional approach to questions about life, death, and phosphorylation.

01-06-2005

Molecular cell

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

04-02-2005

Genes & development

PR72, a novel regulator of Wnt signaling required for Naked cuticle function.

01-02-2005

Blood

Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment.

01-01-2005

Oncogene

An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression.

24-06-2004

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

The Journal of biological chemistry

High incidence of thymic epithelial tumors in E2F2 transgenic mice.

12-03-2004

Nature reviews. Cancer

New tools for functional mammalian cancer genetics.

01-10-2003

Nature

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

14-08-2003

Molecular and cellular biology

Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.

01-05-2003

The Journal of biological chemistry

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

04-04-2003

The New England journal of medicine

A gene-expression signature as a predictor of survival in breast cancer.

19-12-2002

Cancer cell

Stable suppression of tumorigenicity by virus-mediated RNA interference.

01-09-2002

Nature

A progression puzzle.

22-08-2002

Cancer cell

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.

01-07-2002

Science (New York, N.Y.)

A system for stable expression of short interfering RNAs in mammalian cells.

19-04-2002

Cancer letters

Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle.

28-03-2002

Genes & development

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

15-03-2002

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Nature cell biology

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

01-02-2002

Nature

Gene expression profiling predicts clinical outcome of breast cancer.

31-01-2002

Cancer letters

B-myb rescues ras-induced premature senescence, which requires its transactivation domain.

28-09-2001

Nature cell biology

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

01-02-2001

Oncogene

p27kip1-independent cell cycle regulation by MYC.

05-10-2000

Cell

Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.

07-07-2000

Oncogene

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.

06-07-2000

Oncogene

The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.

16-03-2000

Biochimica et biophysica acta

CDK-independent activities of D type cyclins.

29-10-1999

Oncogene

Rapid dephosphorylation of p107 following UV irradiation.

21-01-1999

Oncogene

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.

14-01-1999

Genes & development

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

15-11-1998

Biochimica et biophysica acta

E2F: a nodal point in cell cycle regulation.

09-12-1997

Oncogene

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

01-09-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

FEBS letters

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.

23-06-1997

Cell

CDK-independent activation of estrogen receptor by cyclin D1.

07-02-1997

Genes & development

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

01-12-1996

The Journal of biological chemistry

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.

18-10-1996