Publications

Communications biology

Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types.

13-09-2024

Frontiers in immunology

mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy.

11-09-2024

Acta oncologica (Stockholm, Sweden)

High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency: a discrete choice experiment among healthcare providers.

10-09-2024

Cancer cell

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8⁺ T cells.

09-09-2024

The oncologist

High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer.

06-09-2024

American journal of human genetics

Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset.

05-09-2024

medRxiv : the preprint server for health sciences

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

04-09-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol.

03-09-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

Maximizing Treatment Opportunities: Assessing Protocol Waivers' Impact on Safety and Outcome in the Drug Rediscovery Protocol.

03-09-2024

Toxicology and applied pharmacology

The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites.

01-09-2024

Bioinformatics (Oxford, England)

CIBRA identifies genomic alterations with a system-wide impact on tumor biology.

01-09-2024

Genetics in medicine : official journal of the American College of Medical Genetics

Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.

01-09-2024

European urology open science

Feasibility of Diffuse Reflection Spectroscopy for Intraoperative Margin Assessment During Prostatectomy.

01-09-2024

Clinical pharmacology and therapeutics

Therapeutic Drug Monitoring of Oral Oncology Drugs: Finding the Right Nails.

01-09-2024

British journal of cancer

Reasons for non-feasibility of therapeutic drug monitoring of oral targeted therapies in oncology - an analysis of the closed cohorts of a multicentre prospective study.

01-09-2024

Cancer chemotherapy and pharmacology

A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure-response relationships: a proof-of-concept study with alectinib.

01-09-2024

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: A single-arm phase II trial (CRC-PIPAC-II).

01-09-2024

Journal of cell science

Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers.

01-09-2024

The Journal of urology

Reply by Authors.

01-09-2024

Nature protocols

OBSERVE: guidelines for the refinement of rodent cancer models.

01-09-2024

European journal of cancer (Oxford, England : 1990)

The survival disparity between children and adolescents and young adults (AYAs) with Ewing sarcoma in the Netherlands did not change since the 1990s despite improved survival: A population-based study.

01-09-2024

Trends in cancer

PARPi, BRCA, and gaps: controversies and future research.

01-09-2024

Gynecologic oncology

Effect of reduced follow-up care on patient satisfaction with care among patients with endometrial cancer: The ENSURE randomized controlled trial.

01-09-2024

ESMO open

The clinical use of enfortumab vedotin and pembrolizumab in patients with advanced urothelial carcinoma: using clinical judgement over treatment criteria.

01-09-2024

The Journal of molecular diagnostics : JMD

Mono- and Biallelic Replication-Coupled Gene Editing Discriminates Dominant-Negative and Loss-of-Function Variants of DNA Mismatch Repair Genes.

01-09-2024

The Journal of urology

Location-Based Oncological Outcomes of Sentinel Node Dissection in Radical Prostatectomy.

01-09-2024

BJU international

The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.

01-09-2024

European radiology

Artificial intelligence-assisted double reading of chest radiographs to detect clinically relevant missed findings: a two-centre evaluation.

01-09-2024

European urology focus

A Systematic Review on the Impact of Quality Assurance Programs on Outcomes after Radical Prostatectomy.

01-09-2024

Nature

Mechanisms that clear mutations drive field cancerization in mammary tissue.

01-09-2024

NAR cancer

Ribosome specialization in cancer: a spotlight on ribosomal proteins.

01-09-2024

Pediatric blood & cancer

Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study.

01-09-2024

The Lancet. Oncology

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial.

01-09-2024

British journal of cancer

Invasive recurrence after breast conserving treatment of ductal carcinoma in situ of the breast in the Netherlands: time trends and the association with tumour grade.

01-09-2024

Disability and rehabilitation

Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians.

01-09-2024

Clinical pharmacokinetics

Pharmacokinetics and Pharmacodynamics of Systemic Corticosteroids in Autoimmune and Inflammatory Diseases: A Review of Current Evidence.

01-09-2024

Medical physics

Deep learning-based low-dose CT simulator for non-linear reconstruction methods.

01-09-2024

Nature structural & molecular biology

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

01-09-2024

Fertility and sterility

Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE.

01-09-2024

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Interleukin-6 in relation to early recurrence in primary, localized soft tissue sarcoma: An addition for existing risk classification systems?

01-09-2024

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Prolonged in-use physicochemical and biological stability of nivolumab and pembrolizumab diluted in saline infusion bags and in partially used medication vials.

30-08-2024

Nucleic acids research

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing.

27-08-2024

Oncoimmunology

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products.

27-08-2024

Breast cancer research : BCR

Systematic assessment of HER2 status in ductal carcinoma in situ of the breast: a perspective on the potential clinical relevance.

27-08-2024

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

26-08-2024

Key

European radiology experimental

Non-invasive CT radiomic biomarkers predict microsatellite stability status in colorectal cancer: a multicenter validation study.

26-08-2024

European radiology

Imaging in pelvic exenteration-a multidisciplinary practice guide from the ESGAR-SAR-ESUR-PelvEx collaborative group.

25-08-2024

Therapeutic advances in medical oncology

Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer.

23-08-2024

Journal of experimental & clinical cancer research : CR

Circulating tumour DNA dynamics predict recurrence in stage III melanoma patients receiving neoadjuvant immunotherapy.

21-08-2024

Cell reports. Medicine

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level.

20-08-2024