Publications

British journal of cancer

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.

09-09-2002

Cancer chemotherapy and pharmacology

Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.

01-09-2002

Anti-cancer drugs

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.

01-09-2002

Journal of mass spectrometry : JMS

Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.

01-09-2002

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.

05-08-2002

European journal of cancer (Oxford, England : 1990)

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.

01-08-2002

Cancer chemotherapy and pharmacology

Urinary and fecal excretion of topotecan in patients with malignant solid tumours.

01-07-2002

Cancer chemotherapy and pharmacology

A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.

01-07-2002

Analytical and bioanalytical chemistry

Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry.

01-07-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

01-07-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.

01-06-2002

European journal of drug metabolism and pharmacokinetics

Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors.

09-05-2002

Anti-cancer drugs

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.

01-04-2002

Cancer chemotherapy and pharmacology

Population pharmacokinetics of the novel anticancer agent KRN7000.

01-04-2002

Annals of oncology : official journal of the European Society for Medical Oncology

Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.

01-03-2002

Cancer chemotherapy and pharmacology

Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin.

01-03-2002

Cancer chemotherapy and pharmacology

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

01-02-2002

Anti-cancer drugs

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study.

01-01-2002

The Journal of biological chemistry

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

07-12-2001

Cancer chemotherapy and pharmacology

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.

01-12-2001

Therapeutic drug monitoring

Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen.

01-12-2001

British journal of cancer

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.

16-11-2001

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.

05-11-2001

Journal of chromatography. B, Biomedical sciences and applications

Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography.

05-11-2001

Investigational new drugs

Compatibility and stability of the investigational polypeptide marine anticancer agent kahalalide F in infusion devices.

20-09-2001

Drug development and industrial pharmacy

Development of a lyophilized parenteral pharmaceutical formulation of the investigational polypeptide marine anticancer agent kahalalide F.

01-09-2001

Clinical pharmacokinetics

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach.

29-08-2001

PDA journal of pharmaceutical science and technology

In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol.

17-08-2001

Journal of chromatography. B, Biomedical sciences and applications

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.

05-08-2001

Clinical pharmacology and therapeutics

Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin.

01-08-2001

Anti-cancer drugs

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the oral absorption of paclitaxel.

01-08-2001

Drug metabolism and disposition: the biological fate of chemicals

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites.

01-07-2001

Cancer chemotherapy and pharmacology

Population pharmacokinetics of ifosfamide and its 2- and 3-dechloroethylated and 4-hydroxylated metabolites in resistant small-cell lung cancer patients.

01-07-2001

Bone marrow transplantation

Phase II study of a multi-course high-dose chemotherapy regimen incorporating cyclophosphamide, thiotepa, and carboplatin in stage IV breast cancer.

01-07-2001

European journal of clinical pharmacology

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.

01-07-2001

Journal of chromatography. B, Biomedical sciences and applications

Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma.

15-06-2001

Cancer chemotherapy and pharmacology

Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.

01-06-2001

Journal of pharmacokinetics and pharmacodynamics

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.

01-06-2001

Investigational new drugs

Progress in the development of alternative pharmaceutical formulations of taxanes.

01-05-2001

Investigational new drugs

Oral delivery of taxanes.

01-05-2001

European journal of cancer (Oxford, England : 1990)

Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin.

01-05-2001

Journal of chromatography. B, Biomedical sciences and applications

Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

15-04-2001

Anti-cancer drugs

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

01-04-2001

Biopharmaceutics & drug disposition

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

01-04-2001

Cancer chemotherapy and pharmacology

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.

01-04-2001

Anti-cancer drugs

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.

01-04-2001

Molecular pharmacology

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

01-04-2001

Clinical cancer research : an official journal of the American Association for Cancer Research

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

01-04-2001

Anti-cancer drugs

Ras biochemistry and farnesyl transferase inhibitors: a literature survey.

01-03-2001

Annals of the New York Academy of Sciences

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.

24-02-2001