Publications

Cancer research

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

01-10-2015

eLife

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

01-09-2015

Trends in microbiology

Emerging intracellular receptors for hemorrhagic fever viruses.

01-07-2015

mBio

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.

30-06-2015

Science (New York, N.Y.)

GENE REGULATION. A HUSH for transgene expression.

26-06-2015

mBio

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

26-05-2015

Nature communications

Dissecting the role of aberrant DNA methylation in human leukaemia.

22-05-2015

Genome research

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

01-12-2014

Nature chemical biology

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

01-09-2014

The Journal of biological chemistry

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

29-08-2014

Cancer research

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

15-07-2014

Science (New York, N.Y.)

Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

27-06-2014

Science (New York, N.Y.)

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

06-06-2014

Cell reports

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

10-04-2014

Journal of cell science

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.

01-08-2013

Science (New York, N.Y.)

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

26-04-2013

The Journal of biological chemistry

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

15-03-2013

Molecular cancer research : MCR

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

01-09-2008

Nature methods

shRNA libraries and their use in cancer genetics.

01-09-2006

The British journal of dermatology

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

01-07-2006

Nature chemical biology

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

01-04-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

Methods in enzymology

Functional annotation of deubiquitinating enzymes using RNA interference.

09-11-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Molecular cell

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

04-02-2005

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Nature reviews. Cancer

New tools for functional mammalian cancer genetics.

01-10-2003

Nature

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

14-08-2003

The EMBO journal

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

16-06-2003

Cancer cell

Stable suppression of tumorigenicity by virus-mediated RNA interference.

01-09-2002

Science (New York, N.Y.)

A system for stable expression of short interfering RNAs in mammalian cells.

19-04-2002

Genes & development

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

15-03-2002

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Nature cell biology

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

01-02-2002