Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes
Marcelo Sobral-Leite, Izhar Salomon, Mark Opdam, Dinja T Kruger, Karin J Beelen, Vincent van der Noort, Ronald L P van Vlierberghe, Erik J Blok, Daniele Giardiello, Joyce Sanders, Koen Van de Vijver, Hugo M Horlings, Peter J K Kuppen, Sabine C Linn, Marjanka K Schmidt, Marleen Kok
Breast Cancer Res. 2019 Aug 7;21(1):90. doi: 10.1186/s13058-019-1176-2.
Hierarchical clustering of activated proteins in the PI3K and MAPK pathways in ER-positive, HER2-negative breast cancer with potential therapeutic consequences
Dinja T Kruger, Karin J Beelen, Mark Opdam, Joyce Sanders, Vincent van der Noort, Epie Boven, Sabine C Linn
Br J Cancer. 2018 Oct;119(7):832-839. doi: 10.1038/s41416-018-0221-8. Epub 2018 Oct 5.
Mitotic count can predict tamoxifen benefit in postmenopausal breast cancer patients while Ki67 score cannot
Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest, and Sabine Linn
BMC Cancer. 2018; 18: 761. Published online 2018 Jul 24. doi: 10.1186/s12885-018-4516-1
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Laura J. Esserman, Christina Yau, Carlie K. Thompson, Laura J. van 't Veer, Alexander D. Borowsky, Katherine A. Hoadley, Nicholas P. Tobin, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Christopher C. Benz, and Linda S. Lindström
JAMA Oncol. 2017 Nov; 3(11): 1503–1510. Published online 2017 Jun 29. doi: 10.1001/jamaoncol.2017.1261
St. Gallen endocrine response classes predict recurrence rates over time.
Koornstra RH, Beelen KJ, Vincent AD, van der Noort V, van Diest PJ, Linn SC.
Breast. 2015 Dec;24(6):705-12. doi: 10.1016/j.breast.2015.08.009. Epub 2015 Oct 1
Phosphorylated p-70S6K Predicts Tamoxifen Resistance in Postmenopausal Breast Cancer Patients Randomized Between Adjuvant Tamoxifen Versus No Systemic Treatment
Karin Beelen, Mark Opdam, Tesa M Severson, Rutger H T Koornstra, Andrew D Vincent, Jelle Wesseling, Jettie J Muris, Els M J J Berns, Jan B Vermorken, Paul J van Diest, Sabine C Linn
Breast Cancer Res. 2014 Jan 21;16(1):R6. doi: 10.1186/bcr3598.
Tamoxifen resistance: from bench to bedside.
Droog M, Beelen K, Linn S, Zwart W.
Eur J Pharmacol. 2013 Oct 5;717(1-3):47-57. doi: 10.1016/j.ejphar.2012.11.071. Epub 2013 Mar 29.
Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?
Beelen K, Zwart W, Linn SC.
Nat Rev Clin Oncol. 2012 Sep;9(9):529-41. doi: 10.1038/nrclinonc.2012.121. Epub 2012 Jul 24.