(Cost-)EffectiveNess of a multimodal preHAbilitation program in patients with muscle iNvasive bladder cancer. A tailored multimodal prehabiliation program that compromises an exercise and nutritional intervention for all patients and – in selected patients smoking cessation and/or psychological counseling, preceding radical cystectomy might be an effective way to maintain or improve physical fitness, nutritional status, reduce smoking, and psychological distress, and consequently reduce the number of perioperative complications. The ENHANCE study ((Cost-)EffectiveNess of a multimodal preHAbilitation program in patients with muscle iNvasive bladder cancer) is a multicenter randomized controlled trial aiming to include 154 patients with muscle invasive bladder cancer. Patients will be randomized to either control group or intervention group. The intervention group will receive a tailored exercise program and nutritional counseling, smoking cessation assistance will be provided if relevant and patients who have clinically relevant anxiety and/or depression will be referred to an appropriate health profession. The control group will receive usual care. The main objective is to study the effectiveness of a multimodal prehabilitation program preceding radical cystectomy in reducing the proportion of patients having grade 2 or higher perioperative complications within 90 days.