We have generated genetically engineered mouse models (GEMMs) for BRCA1-associated breast cancer 1 2.
We have generated GEMMs for BRCA2-associated breast cancer 1.
We have generated GEMMs for E-cadherin mutated invasive lobular breast cancer 1 2 3 .
We have generated BRCA-proficient and BRCA1/2-deficient mouse mammary tumor organoids to study cancer-drug resistance 1 .
We have developed methods for somatic modeling of breast cancer in mice via intraductal injection of lentiviruses encoding oncogenes or sgRNAs targeting tumor suppressor genes 1 2 3.