Jos Jonkers
Mouse Models of Breast Cancer
My group studies human breast cancer development and progression, as well as therapy response and resistance, in genetically engineered mouse models (GEMMs) and patient-derived tumor xenograft (PDX) models.
We have developed mouse models for BRCA1/2-associated breast cancer and invasive lobular carcinoma (ILC), which are used to (1) study tumor cell-intrinsic and -extrinsic mechanisms of breast cancer development and progression; (2) develop novel therapeutic strategies for prevention and treatment of breast tumors; (3) study mechanisms of acquired resistance to targeted therapeutics.