Lesion detection by [⁸⁹Zr]Zr-DFO-girentuximab and [¹⁸F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma.

Abstract

CONCLUSIONS

The addition of [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and [¹⁸F]FDG-PET/CT to CT increases lesion detection compared to CT alone in newly diagnosed good and intermediate prognosis mccRCC patients eligible for watchful waiting.

METHODS

Between February 2015 and March 2018, 42 newly diagnosed mccRCC patients with good or intermediate prognosis, eligible for watchful waiting, were included. Patients underwent CT, [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and [¹⁸F]FDG-PET/CT at baseline. Scans were independently reviewed and lesions of ≥10 mm and lymph nodes of ≥15 mm at CT were analyzed. For lesions with [⁸⁹Zr]Zr-DFO-girentuximab or [¹⁸F]FDG-uptake visually exceeding background uptake, maximum standardized uptake values (SUV_max) were measured.

PURPOSE

The main objective of this preliminary analysis of the IMaging PAtients for Cancer drug selecTion (IMPACT)-renal cell cancer (RCC) study is to evaluate the lesion detection of baseline contrast-enhanced CT, [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and [¹⁸F]FDG-PET/CT in detecting ccRCC lesions in patients with a good or intermediate prognosis metastatic clear cell renal cell carcinoma (mccRCC) according to the International Metastatic Database Consortium (IMDC) risk model.

RESULTS

A total of 449 lesions were detected by ≥1 modality (median per patient: 7; ICR 4.25-12.75) of which 42% were in lung, 22% in lymph nodes and 10% in bone. Combined [⁸⁹Zr]Zr-DFO-girentuximab-PET/CT and CT detected more lesions than CT alone: 91% (95%CI: 87-94) versus 56% (95%CI: 50-62, p = 0.001), respectively, and more than CT and [¹⁸F]FDG-PET/CT combined (84% (95%CI:79-88, p < 0.005). Both PET/CTs detected more bone and soft tissue lesions compared to CT alone.