Publications

Cancer research

Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines.

01-08-2018

Cell reports

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.

26-06-2018

Cell research

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.

01-06-2018

Molecular cancer therapeutics

PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma.

01-04-2018

Cell reports

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.

17-10-2017

European urology

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma.

01-06-2017

Stem cells (Dayton, Ohio)

TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.

01-01-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

01-11-2016

Methods in molecular biology (Clifton, N.J.)

Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform.

02-09-2016

Oncotarget

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.

12-07-2016

Molecular cancer therapeutics

Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.

01-07-2016

Oncotarget

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling.

21-06-2016

Nature biotechnology

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

01-06-2016

Cell

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

07-04-2016

Oncotarget

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation.

19-01-2016

Scientific reports

The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.

01-10-2015

Cell reports

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

29-09-2015

Nucleic acids research

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference.

20-04-2015

Bioscience reports

Identification of signalling cascades involved in red blood cell shrinkage and vesiculation.

16-04-2015

Cell research

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.

01-04-2015

Oncogene

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.

22-01-2015

Cell reports

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

20-11-2014

Proceedings of the National Academy of Sciences of the United States of America

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

21-10-2014

Molecular systems biology

The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality.

01-07-2014

Cell reports

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

10-04-2014

Nature

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

03-04-2014

Molecular and cellular biology

The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling.

01-08-2013

Cell

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.

21-11-2012

Journal of cellular and molecular medicine

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

01-09-2012

Nature

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

26-01-2012

The Journal of experimental medicine

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.

19-12-2011

PloS one

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

08-10-2011

Cancer discovery

Functional subtyping of breast cancer.

01-08-2011

Cell

A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation.

15-04-2011

Cell cycle (Georgetown, Tex.)

Screening for modulators of cisplatin sensitivity: unbiased screens reveal common themes.

01-02-2011

IDrugs : the investigational drugs journal

Using large-scale RNAi screens to identify novel drug targets for cancer.

01-11-2010

Future oncology (London, England)

Exploration of synthetic lethal interactions as cancer drug targets.

01-11-2010

Molecular cancer research : MCR

Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.

01-04-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.

15-09-2009

Cancer cell

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

07-04-2009

PloS one

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

12-03-2009

Nature

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

29-11-2007

Cancer cell

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

01-10-2007

The Journal of biological chemistry

Telomerase-independent regulation of ATR by human telomerase RNA.

29-12-2006

Nature methods

shRNA libraries and their use in cancer genetics.

01-09-2006

Nature chemical biology

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

01-04-2006

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Cell

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

17-06-2005

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Genes & development

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

01-12-1996