Publications

British journal of clinical pharmacology

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

01-05-2016

Journal of neurology

Strategies to target drugs to gliomas and CNS metastases of solid tumors.

01-03-2016

The AAPS journal

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer.

01-03-2016

Obesity surgery

Proton Pump Inhibitor Prophylaxis After Gastric Bypass Does Not Cause Hypomagnesemia.

01-03-2016

Lung cancer (Amsterdam, Netherlands)

Crizotinib-induced fatal fulminant liver failure.

01-03-2016

Haematologica

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).

01-03-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.

15-02-2016

European journal of cancer (Oxford, England : 1990)

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care.

01-02-2016

Cancers

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer.

02-01-2016

Bioanalysis

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS.

15-12-2015

Cancer treatment reviews

The use of combinations of monoclonal antibodies in clinical oncology.

01-12-2015

Investigational new drugs

Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer.

01-12-2015

Journal of cancer research and clinical oncology

Epstein-Barr virus-targeted therapy in nasopharyngeal carcinoma.

01-10-2015

British journal of clinical pharmacology

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function.

01-08-2015

Clinical pharmacokinetics

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

01-08-2015

CPT: pharmacometrics & systems pharmacology

Integrated Simulation Framework for Toxicity, Dose Intensity, Disease Progression, and Cost Effectiveness for Castration-Resistant Prostate Cancer Treatment With Eribulin.

01-07-2015

Clinical lung cancer

Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy.

01-07-2015

CPT: pharmacometrics & systems pharmacology

Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin.

01-07-2015

JAMA oncology

Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil.

01-06-2015

British journal of clinical pharmacology

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

01-05-2015

BioMed research international

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

30-04-2015

Pharmacology research & perspectives

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses.

01-03-2015

European journal of clinical pharmacology

Baclofen overdose treated with continuous venovenous hemofiltration.

01-03-2015

International journal of pharmaceutics

Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy.

01-02-2015

Investigational new drugs

Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas.

01-02-2015

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Dosing of carboplatin in a patient with amputated legs: A case report.

01-12-2014

Pediatric blood & cancer

Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

01-12-2014

Drugs & aging

Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study.

01-10-2014

Investigational new drugs

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error.

01-10-2014

Annals of oncology : official journal of the European Society for Medical Oncology

Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel.

01-10-2014

Nederlands tijdschrift voor geneeskunde

[Hyperglycaemia during treatment with everolimus].

15-08-2014

Clinical pharmacology and therapeutics

Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662.

01-07-2014

Therapeutic drug monitoring

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care.

01-06-2014

British journal of cancer

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.

13-05-2014

Current clinical pharmacology

Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer.

01-05-2014

Clinical pharmacokinetics

Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets.

01-04-2014

BioMed research international

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy.

29-03-2014

Clinical pharmacokinetics

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study.

01-03-2014

Journal of pharmaceutical sciences

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

01-02-2014

BMC cancer

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.

28-12-2013

European journal of clinical pharmacology

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome.

01-12-2013

Gynecologic oncology

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

01-09-2013

British journal of clinical pharmacology

Population pharmacokinetic-pharmacodynamic analysis for eribulin mesilate-associated neutropenia.

01-09-2013

Medical decision making : an international journal of the Society for Medical Decision Making

Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

01-08-2013

Journal of clinical pharmacology

A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors.

01-08-2013

British journal of clinical pharmacology

Optimizing drug development of anti-cancer drugs in children using modelling and simulation.

01-07-2013

Antimicrobial agents and chemotherapy

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

01-06-2013

Drug delivery and translational research

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet.

01-06-2013

Therapeutic drug monitoring

Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring.

01-04-2013

Biomedical chromatography : BMC

Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.

01-04-2013