Publications

Lancet (London, England)

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial.

01-08-2015

Nature reviews. Cancer

Evolving synergistic combinations of targeted immunotherapies to combat cancer.

01-08-2015

The New England journal of medicine

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

02-07-2015

Gene therapy

Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines.

01-07-2015

British journal of cancer

Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma.

30-06-2015

Seminars in oncology

Toxicity patterns with immunomodulating antibodies and their combinations.

01-06-2015

European journal of cancer (Oxford, England : 1990)

Vemurafenib for BRAF V600 mutated advanced melanoma: results of treatment beyond progression.

01-03-2015

Journal of translational medicine

NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy.

27-01-2015

Nature medicine

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

01-01-2015

Nature communications

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

15-12-2014

Science (New York, N.Y.)

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

03-10-2014

Human gene therapy methods

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

01-10-2014

Science translational medicine

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

17-09-2014

Molecular oncology

Acquired and intrinsic resistance in cancer immunotherapy.

12-09-2014

Cancer immunology research

Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy.

01-06-2014

British journal of cancer

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.

13-05-2014

Cancer immunology, immunotherapy : CII

Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma.

01-05-2014

Methods in molecular biology (Clifton, N.J.)

Intradermal vaccination by DNA tattooing.

10-04-2014

Nature

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

03-04-2014

The Lancet. Oncology

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.

01-03-2014

World journal of urology

Do targeted agents offer clinical benefit as presurgical therapy?

01-02-2014

BMC cancer

Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma.

01-12-2013

European journal of clinical pharmacology

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome.

01-12-2013

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.

10-11-2013

Nature medicine

High-throughput identification of antigen-specific TCRs by TCR gene capture.

01-11-2013

Acta oncologica (Stockholm, Sweden)

Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O).

01-11-2013

Annals of oncology : official journal of the European Society for Medical Oncology

Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20).

01-10-2013

EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.]

Immunotherapy of melanoma.

01-09-2013

Vaccine

Transposon leads to contamination of clinical pDNA vaccine.

11-07-2013

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Vemurafenib as neoadjuvant treatment for unresectable regional metastatic melanoma.

01-06-2013

Cancer treatment reviews

Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?

01-06-2013

The Netherlands journal of medicine

Recent advances towards the clinical application of DNA vaccines.

01-04-2013

Human gene therapy

Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses.

01-12-2012

Proceedings of the National Academy of Sciences of the United States of America

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

27-11-2012

Oncoimmunology

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

01-07-2012

Advances in immunology

Behavior and function of tissue-resident memory T cells.

28-03-2012

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

10-01-2012

Lancet (London, England)

Tilting the AXIS towards therapeutic limits in renal cancer.

03-12-2011

Nederlands tijdschrift voor geneeskunde

[Issues around melanoma].

17-11-2011

Urology

A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ.

01-10-2011

Cancer immunology, immunotherapy : CII

Combination of targeted therapy and immunotherapy in melanoma.

01-10-2011

International journal of cancer

Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7.

15-07-2011

Annals of oncology : official journal of the European Society for Medical Oncology

The safety and efficacy of sunitinib before planned nephrectomy in metastatic clear cell renal cancer.

01-05-2011

Clinical and experimental immunology

Lack of anti-tumour reactivity despite enhanced numbers of circulating natural killer T cells in two patients with metastatic renal cell carcinoma.

01-12-2010

Current topics in microbiology and immunology

DNA vaccines and intradermal vaccination by DNA tattooing.

26-11-2010

Human gene therapy

Microbead-assisted retroviral transduction for clinical application.

01-10-2010

Cancer immunology, immunotherapy : CII

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells.

01-08-2010

Current clinical pharmacology

DNA vaccination in oncology: current status, opportunities and perspectives.

01-08-2010

Annals of oncology : official journal of the European Society for Medical Oncology

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.

01-07-2010

International journal of pharmaceutics

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

05-05-2010