Publications

Cancer chemotherapy and pharmacology

Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids.

01-05-2018

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

American Society of Clinical Oncology Statement: Biosimilars in Oncology.

20-04-2018

Psycho-oncology

Managing unsolicited findings in genomics: A qualitative interview study with cancer patients.

01-04-2018

Familial cancer

Cancer patients' intentions towards receiving unsolicited genetic information obtained using next-generation sequencing.

01-04-2018

Nephron

The von Hippel-Lindau Gene Is Required to Maintain Renal Proximal Tubule and Glomerulus Integrity in Zebrafish Larvae.

18-01-2018

Cell

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

11-01-2018

Trends in molecular medicine

Is It Our Duty To Hunt for Pathogenic Mutations?

01-01-2018

Annals of oncology : official journal of the European Society for Medical Oncology

Molecular Tumor Boards: current practice and future needs.

01-12-2017

The oncologist

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.

01-12-2017

The oncologist

Fixed Dosing of Monoclonal Antibodies in Oncology.

01-10-2017

Cell chemical biology

Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.

21-09-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity.

15-09-2017

ESMO open

Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers.

30-08-2017

Oncotarget

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.

15-08-2017

Cancer research

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.

15-07-2017

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

01-05-2017

Annals of oncology : official journal of the European Society for Medical Oncology

Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

01-05-2017

JAMA oncology

Alternating Treatment With Pazopanib and Everolimus vs Continuous Pazopanib to Delay Disease Progression in Patients With Metastatic Clear Cell Renal Cell Cancer: The ROPETAR Randomized Clinical Trial.

01-04-2017

ESMO open

Career opportunities and benefits for young oncologists in the European Society for Medical Oncology (ESMO).

04-03-2017

Intravital

Intravital characterization of tumor cell migration in pancreatic cancer.

01-03-2017

Neoplasia (New York, N.Y.)

Randomized Phase III Study to Assess Efficacy and Safety of Adjuvant CAPOX with or without Bevacizumab in Patients after Resection of Colorectal Liver Metastases: HEPATICA study.

01-02-2017

The oncologist

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.

01-01-2017

Human mutation

Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing.

01-12-2016

ESMO open

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

16-11-2016

JAMA oncology

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review.

01-11-2016

European journal of human genetics : EJHG

Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.

01-10-2016

Oncogene

Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.

04-08-2016

Annals of oncology : official journal of the European Society for Medical Oncology

The time to progression ratio: a new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies.

01-08-2016

Cell reports

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

28-06-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.

15-06-2016

Nature medicine

Facilitating a culture of responsible and effective sharing of cancer genome data.

05-05-2016

Investigational new drugs

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.

01-04-2016

Cell reports

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity.

15-03-2016

PloS one

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

27-02-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.

15-02-2016

Cancer discovery

DNA-Guided Precision Medicine for Cancer: A Case of Irrational Exuberance?

01-02-2016

Proceedings of the National Academy of Sciences of the United States of America

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

27-10-2015

Breast cancer research : BCR

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response.

03-10-2015

JAMA oncology

Let Them Eat Fish--Reply.

01-09-2015

EMBO molecular medicine

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.

01-09-2015

British journal of cancer

Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours.

01-09-2015

British journal of clinical pharmacology

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function.

01-08-2015

JAMA oncology

Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil.

01-06-2015

Anticancer research

Effective Therapeutic Intervention and Comprehensive Genetic Analysis of mTOR Signaling in PEComa: A Case Report.

01-06-2015

Clinical cancer research : an official journal of the American Association for Cancer Research

Dose-response relationship in phase i clinical trials: a European Drug Development Network (EDDN) Collaboration Study.

15-11-2014

Nature communications

Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response.

12-11-2014

Annals of oncology : official journal of the European Society for Medical Oncology

Outcome of patients with sarcoma and other mesenchymal tumours participating in phase I trials: a subset analysis of a European Phase I database.

01-06-2014

Proceedings of the National Academy of Sciences of the United States of America

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

20-05-2014

British journal of cancer

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.

13-05-2014

Investigational new drugs

Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors.

01-08-2013