Publications

Nature medicine

Delivering precision oncology to patients with cancer.

01-04-2022

Clinical cancer research : an official journal of the American Association for Cancer Research

Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment.

01-04-2022

Clinical cancer research : an official journal of the American Association for Cancer Research

Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments.

01-03-2022

Nature cancer

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

01-02-2022

The Lancet. Oncology

Harmonising patient-access programmes: the Dutch DRUG Access Protocol platform.

01-02-2022

Cancers

Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients.

16-01-2022

Frontiers in medicine

Extension of Indication for Authorised Oncology Products in the European Union: A Joint Effort of Multiple Stakeholders.

28-12-2021

Clinical cancer research : an official journal of the American Association for Cancer Research

Patients with Biallelic BRCA1/2 Inactivation Respond to Olaparib Treatment Across Histologic Tumor Types.

15-11-2021

Molecular oncology

The Porto European Cancer Research Summit 2021.

01-10-2021

Cancer cell

Tumor organoids: Opportunities and challenges to guide precision medicine.

13-09-2021

Nature medicine

Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

01-09-2021

Cancer cell

Developing and validating model systems for immuno-oncology.

09-08-2021

Cancer discovery

Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.

01-08-2021

ESMO open

Prospective experimental treatment of colorectal cancer patients based on organoid drug responses.

01-06-2021

Frontiers in endocrinology

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.

30-03-2021

BMC medical genomics

Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE).

10-11-2020

Clinical and translational radiation oncology

Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system.

01-09-2020

Molecular oncology

Towards a cancer mission in Horizon Europe: recommendations.

01-08-2020

Nature medicine

Author Correction: Caring for patients with cancer in the COVID-19 era.

01-07-2020

Nature medicine

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

01-07-2020

Learning health systems

Learning health care systems: Highly needed but challenging.

01-07-2020

Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020

Nature communications

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.

05-06-2020

European journal of cancer (Oxford, England : 1990)

Patients with cancer in the era of 2019 novel coronavirus disease.

01-06-2020

Cell reports

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine.

05-05-2020

Nature medicine

Caring for patients with cancer in the COVID-19 era.

01-05-2020

Nature medicine

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.

01-04-2020

Molecular cancer research : MCR

Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity.

01-04-2020

ESMO open

Preferences to receive unsolicited findings of germline genome sequencing in a large population of patients with cancer.

01-04-2020

The Journal of pathology

BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers.

01-02-2020

Nature protocols

Tumor organoid-T-cell coculture systems.

01-01-2020

Nature communications

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

20-11-2019

Nature

Pan-cancer whole-genome analyses of metastatic solid tumours.

01-11-2019

Science translational medicine

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

09-10-2019

Nature genetics

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

01-10-2019

Annals of oncology : official journal of the European Society for Medical Oncology

When is off-label off-road?

01-10-2019

Endocrine-related cancer

The molecular genetic make-up of male breast cancer.

01-10-2019

British journal of cancer

Molecular tumour boards and molecular diagnostics for patients with cancer in the Netherlands: experiences, challenges, and aspirations.

01-07-2019

ESMO open

Advancing molecular tumour boards: highly needed to maximise the impact of precision medicine.

25-06-2019

European journal of cancer (Oxford, England : 1990)

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology.

01-06-2019

Cell

Identifying Epistasis in Cancer Genomes: A Delicate Affair.

30-05-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients.

01-05-2019

Molecular oncology

Cancer Core Europe: A translational research infrastructure for a European mission on cancer.

01-03-2019

The EMBO journal

Long-term expanding human airway organoids for disease modeling.

15-02-2019

JCO precision oncology

Rationale and Design of the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

04-01-2019

Nature medicine

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.

01-01-2019

International journal of cancer

Detection of endogenously circulating mesenchymal stem cells in human cancer patients.

15-11-2018

European journal of cancer (Oxford, England : 1990)

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

01-11-2018

JCO precision oncology

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL.

16-08-2018

Nederlands tijdschrift voor geneeskunde

[Ethical dilemmas in a general practitioner's clinic due to incidental findings resulting from whole genome sequencing].

15-06-2018