Publications

FEBS letters

Decoding microtubule detyrosination: enzyme families, structures, and functional implications.

01-06-2024

Journal of cell science

Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility.

01-05-2024

Protein science : a publication of the Protein Society

Conserved proline residues prevent dimerization and aggregation in the β-lactamase BlaC.

01-04-2024

ACS chemical biology

Targeting the Main Protease (M^pro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.

16-02-2024

Nature reviews. Molecular cell biology

Challenges and opportunities in macromolecular structure determination.

01-01-2024

Life science alliance

Distant sequence regions of JBP1 contribute to J-DNA binding.

01-09-2023

Acta crystallographica. Section D, Structural biology

The CCP4 suite: integrative software for macromolecular crystallography.

01-06-2023

Journal of visualized experiments : JoVE

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy.

03-03-2023

Nature methods

AlphaFill: enriching AlphaFold models with ligands and cofactors.

01-02-2023

Cell chemical biology

Autotaxin facilitates selective LPA receptor signaling.

19-01-2023

Journal of structural biology

Crystal structure of the phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain.

01-12-2022

The Journal of cell biology

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

07-11-2022

EMBO molecular medicine

A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis.

07-09-2022

Nature

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-08-2022

Science (New York, N.Y.)

Posttranslational modification of microtubules by the MATCAP detyrosinase.

20-05-2022

Frontiers in pharmacology

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells.

14-05-2022

Journal of medicinal chemistry

Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.

28-04-2022

Nature

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-03-2022

The Journal of biological chemistry

Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity.

01-02-2022

Proteins

Target highlights in CASP14: Analysis of models by structure providers.

01-12-2021

Cell reports

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8⁺ T cells.

16-11-2021

Journal of visualized experiments : JoVE

iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology.

16-11-2021

EMBO reports

AI revolutions in biology: The joys and perils of AlphaFold.

04-11-2021

Journal of medicinal chemistry

Imaging Autotaxin In Vivo with ¹⁸F-Labeled Positron Emission Tomography Ligands.

28-10-2021

The FEBS journal

Conserved residues Glu37 and Trp229 play an essential role in protein folding of β-lactamase.

01-10-2021

Acta crystallographica. Section D, Structural biology

New restraints and validation approaches for nucleic acid structures in PDB-REDO.

01-09-2021

Acta crystallographica. Section D, Structural biology

CCD²: design constructs for protein expression, the easy way.

01-08-2021

Biochemistry

The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam.

20-07-2021

Antimicrobial agents and chemotherapy

Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics.

16-07-2021

Journal of visualized experiments : JoVE

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery.

16-05-2021

Acta crystallographica. Section D, Structural biology

LAHMA: structure analysis through local annotation of homology-matched amino acids.

01-01-2021

Analytical biochemistry

Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein.

01-12-2020

Structure (London, England : 1993)

A Global Ramachandran Score Identifies Protein Structures with Unlikely Stereochemistry.

03-11-2020

F1000Research

A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).

23-06-2020

Journal of cell science

Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.

10-02-2020

Cancers

The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions.

16-10-2019

The Journal of biological chemistry

The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity.

23-08-2019

Nature structural & molecular biology

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

01-07-2019

Acta crystallographica. Section D, Structural biology

Building and rebuilding N-glycans in protein structure models.

01-04-2019

Proteins

A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.

01-04-2019

Journal of structural biology: X

West-Life: A Virtual Research Environment for structural biology.

26-02-2019

Cell reports

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

19-02-2019

The Journal of biological chemistry

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

14-12-2018

Life science alliance

Direct binding of Cdt2 to PCNA is important for targeting the CRL4^Cdt2 E3 ligase activity to Cdt1.

01-12-2018

Acta crystallographica. Section F, Structural biology communications

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

01-11-2018

The Journal of biological chemistry

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

14-09-2018

IUCrJ

Homology-based loop modeling yields more complete crystallographic protein structures.

01-09-2018

Nature cell biology

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

01-07-2018

Protein science : a publication of the Protein Society

Homology-based hydrogen bond information improves crystallographic structures in the PDB.

01-03-2018

The international journal of biochemistry & cell biology

Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

01-01-2018