Publications

Cell reports

The Cancer SENESCopedia: A delineation of cancer cell senescence.

27-07-2021

Nature cell biology

Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.

01-07-2021

Nature

EGFR activation limits the response of liver cancer to lenvatinib.

01-07-2021

Nature cell biology

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.

01-06-2021

Cancer discovery

Thinking Differently about Cancer Treatment Regimens.

01-05-2021

The oncologist

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

01-04-2021

Cancers

Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells.

05-03-2021

Genome medicine

Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.

10-02-2021

British journal of cancer

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

01-01-2021

Cancer research

A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer.

15-11-2020

International journal of cancer

Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis.

15-10-2020

eLife

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.

05-10-2020

Molecular oncology

Towards a cancer mission in Horizon Europe: recommendations.

01-08-2020

PloS one

Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene.

09-07-2020

Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020

Cancer chemotherapy and pharmacology

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.

01-05-2020

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

01-04-2020

Future oncology (London, England)

Vorinostat in patients with resistant BRAF^V600E mutated advanced melanoma: a proof of concept study.

01-04-2020

Gut

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.

01-04-2020

Future oncology (London, England)

Encorafenib, binimetinib and cetuximab combined therapy for patients with BRAFV600E mutant metastatic colorectal cancer.

01-02-2020

Translational oncology

RUNX2/CBFB modulates the response to MEK inhibitors through activation of receptor tyrosine kinases in KRAS-mutant colorectal cancer.

01-02-2020

Nature cancer

A roadmap for the next decade in cancer research.

01-01-2020

Clinical cancer research : an official journal of the American Association for Cancer Research

BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer.

01-12-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.

01-12-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients.

15-11-2019

Nature

Inducing and exploiting vulnerabilities for the treatment of liver cancer.

01-10-2019

Cancer letters

Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma.

01-10-2019

The Journal of molecular diagnostics : JMD

MammaPrint and BluePrint Molecular Diagnostics Using Targeted RNA Next-Generation Sequencing Technology.

01-09-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.

15-07-2019

Nature cell biology

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities.

01-06-2019

Cancer research

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer.

15-05-2019

NPJ breast cancer

Estrogen receptor variants in ER-positive basal-type breast cancers responding to therapy like ER-negative breast cancers.

25-04-2019

Oncoimmunology

Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival.

14-12-2018

Molecular & cellular oncology

With great power comes great vulnerability.

14-12-2018

Genome medicine

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.

27-11-2018

Journal of hepatology

Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.

01-11-2018

Molecular & cellular proteomics : MCP

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

01-10-2018

Trends in molecular medicine

An Experimenter's Guide to Glioblastoma Invasion Pathways.

01-09-2018

The Journal of clinical investigation

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies.

31-08-2018

Clinical cancer research : an official journal of the American Association for Cancer Research

Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

15-08-2018

Oncogene

ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors.

01-08-2018

Frontiers of medicine

Taking advantage of drug resistance, a new approach in the war on cancer.

01-08-2018

Cell research

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

01-07-2018

Nature medicine

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

01-07-2018

Cell research

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.

01-06-2018

Cell

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

31-05-2018

The EMBO journal

Anti-cancer therapy: senescence is the new black.

15-05-2018

Molecular cancer therapeutics

PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma.

01-04-2018

Hepatology (Baltimore, Md.)

In vivo veritas: Finding novel genes involved in liver cancer through in vivo genetic screens.

01-12-2017

Annals of surgical oncology

Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.

01-12-2017