Publications

Clinical pharmacokinetics

Clinical pharmacokinetics of topotecan.

01-08-1996

European journal of cancer (Oxford, England : 1990)

The toxicity of radiotherapy following high-dose chemotherapy with peripheral blood stem cell support in high-risk breast cancer: a preliminary analysis.

01-08-1996

Journal of the National Cancer Institute

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.

17-07-1996

Journal of chromatography. B, Biomedical applications

Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography.

07-06-1996

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Palliative effect of metaiodobenzylguanidine in metastatic carcinoid tumors.

01-06-1996

Drug metabolism and disposition: the biological fate of chemicals

Isolation, purification and biological activity of major docetaxel metabolites from human feces.

01-06-1996

Cancer research

Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.

01-05-1996

British journal of cancer

Efficacy of up-front 5-fluorouracil-epidoxorubicin-cyclophosphamide (FEC) chemotherapy with an increased dose of epidoxorubicin in high-risk breast cancer patients.

01-05-1996

British journal of cancer

Pharmacokinetics and pharmacodynamics of carboplatin administered in a high-dose combination regimen with thiotepa, cyclophosphamide and peripheral stem cell support.

01-04-1996

Cancer chemotherapy and pharmacology

Unchanged pharmacokinetics of etoposide given by intra-arterial hepatic infusion as compared with i.v. infusion.

01-01-1996

Cancer chemotherapy and pharmacology

Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure.

01-01-1996

Investigational new drugs

Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9.

01-01-1996

Anti-cancer drugs

Tissue distribution, metabolism and excretion of paclitaxel in mice.

01-01-1996

Cancer chemotherapy and pharmacology

Evaluation of formulas using the serum creatinine level to calculate the optimal dosage of carboplatin.

01-01-1996

Journal of chromatography. B, Biomedical applications

Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.

15-12-1995

Journal of pharmaceutical and biomedical analysis

High-performance liquid chromatographic analysis of the new antitumour drug N-benzoylstaurosporine (CGP 41 251) and four potential metabolites in micro-volumes of plasma.

01-12-1995

PDA journal of pharmaceutical science and technology

The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244).

01-11-1995

Proceedings of the National Academy of Sciences of the United States of America

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

15-08-1995

British journal of cancer

CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs.

01-07-1995

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.

01-07-1995

Journal of chromatography. B, Biomedical applications

High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma.

09-06-1995

Cancer treatment reviews

High-dose chemotherapy regimens for solid tumors.

01-03-1995

Journal of cancer research and clinical oncology

The use of the Calvert formula to determine the optimal carboplatin dosage.

01-01-1995

Cancer chemotherapy and pharmacology

Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces.

01-01-1995

British journal of cancer

Melphalan tissue concentrations in patients treated with regional isolated perfusion for melanoma of the lower limb.

01-07-1994

Cell

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

20-05-1994

Annals of oncology : official journal of the European Society for Medical Oncology

Intraperitoneal-administered carboplatin in patients with ovarian cancer; influence of a dwell-time on toxicity and response.

01-02-1994

Journal of chromatography

Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma.

14-01-1994

Cancer chemotherapy and pharmacology

Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination.

01-01-1994

Cancer chemotherapy and pharmacology

Pharmaceutical development of a parenteral lyophilized formulation of the novel indoloquinone antitumor agent EO9.

01-01-1994

Cancer chemotherapy and pharmacology

The pharmacokinetics of reduced folates after intraperitoneal and intravenous administration of racemic [6S,R]-folinic acid.

01-01-1994

Annals of oncology : official journal of the European Society for Medical Oncology

Etoposide, leucovorin, 5-fluorouracil (ELF) combination chemotherapy for advanced gastric cancer: experience with two treatment schedules incorporating intravenous or oral etoposide.

01-01-1994

Cancer chemotherapy and pharmacology

Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report.

01-01-1994

Investigational new drugs

Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244).

01-01-1994

Cancer chemotherapy and pharmacology

Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography.

01-01-1994

Pharmacy world & science : PWS

Signal transduction pathways: new targets in oncology.

17-12-1993

Journal of pharmaceutical and biomedical analysis

Chemical stability of the new antitumour agent intoplicine in infusion fluids.

01-11-1993

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.

01-11-1993

Anticancer research

Clinical pharmacokinetics and pharmacodynamics of anticancer agents in pediatric patients (review).

01-09-1993

Journal of parenteral science and technology : a publication of the Parenteral Drug Association

Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids.

01-07-1993

Investigational new drugs

Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinorelbine in mice as determined by high performance liquid chromatography.

01-05-1993

Cancer research

Plasma pharmacokinetics of vinblastine and the investigational Vinca alkaloid N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate in mice as determined by high-performance liquid chromatography.

01-05-1993

Cancer chemotherapy and pharmacology

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography.

01-01-1993

European journal of cancer (Oxford, England : 1990)

Reconstitution of recombinant interleukin-2 (rIL-2): a comparative study of various rIL-2 muteins.

01-01-1993

Anticancer research

Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review).

01-09-1992

Pharmaceutisch weekblad. Scientific edition

New cytotoxic drugs and targets in oncology.

21-08-1992

Journal of parenteral science and technology : a publication of the Parenteral Drug Association

Chemical stability of two sterile, parenteral formulations of cyclophosphamide (Endoxan) after reconstitution and dilution in commonly used infusion fluids.

01-07-1992

British journal of cancer

A phase I study of prolonged continuous infusion of low dose recombinant interleukin-2 in melanoma and renal cell cancer. Part I: Clinical aspects.

01-05-1992

Journal of chromatography

Bioanalysis of the investigational anti-tumour drug 5,10-dideaza-5,6,7,8-tetrahydrofolic acid by high-performance liquid chromatography with ultraviolet detection.

15-04-1992

The Annals of pharmacotherapy

Effect of cisplatin-containing chemotherapy on lithium serum concentrations.

01-04-1992