Publications

British journal of cancer

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).

01-02-1999

Therapeutic drug monitoring

Sampling technique from central venous catheters proves critical for pharmacokinetic studies.

01-02-1999

British journal of cancer

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG).

01-02-1999

Anti-cancer drugs

Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.

01-01-1999

British journal of cancer

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein.

01-01-1999

Investigational new drugs

Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].

16-12-1998

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic bio-analysis of PSC 833 in human and murine plasma.

20-11-1998

Journal of mass spectrometry : JMS

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-11-1998

The Annals of pharmacotherapy

Hepatitis during chloroguanide prophylaxis.

01-10-1998

Cancer treatment reviews

In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide.

01-10-1998

Clinical cancer research : an official journal of the American Association for Cancer Research

Enhanced oral absorption and decreased elimination of paclitaxel in mice cotreated with cyclosporin A.

01-10-1998

Journal of chromatography. B, Biomedical sciences and applications

High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes.

25-09-1998

Journal of chromatography. B, Biomedical sciences and applications

Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography.

25-09-1998

The Journal of experimental medicine

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage.

07-09-1998

Anti-cancer drugs

Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.

01-09-1998

Pharmacological research

Pharmacologic study of 3-hour 135 mg M-2 paclitaxel in platinum pretreated patients with advanced ovarian cancer.

01-09-1998

Journal of pharmaceutical and biomedical analysis

High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarboxylate forms, in micro-volumes of human plasma.

01-09-1998

Journal of chromatography. B, Biomedical sciences and applications

Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography.

07-08-1998

Anti-cancer drugs

O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan.

01-08-1998

Journal of chromatography. B, Biomedical sciences and applications

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.

12-06-1998

Anti-cancer drugs

Continuous infusion of low-dose topotecan: pharmacokinetics and pharmacodynamics during a phase II study in patients with small cell lung cancer.

01-06-1998

Pharmacological research

The pharmacological role of P-glycoprotein in the intestinal epithelium.

01-06-1998

Cancer research

Comparative pharmacology of the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats, and humans.

01-06-1998

Journal of chromatography. B, Biomedical sciences and applications

Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.

08-05-1998

Cancer chemotherapy and pharmacology

A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study.

02-04-1998

Annals of oncology : official journal of the European Society for Medical Oncology

Malignant effusions contain lysophosphatidic acid (LPA)-like activity.

01-04-1998

Cancer treatment reviews

Cisplatin resistance and DNA repair.

18-02-1998

European journal of cancer (Oxford, England : 1990)

Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.

01-01-1998

Pharmacological research

Clinical research on antiangiogenic therapy.

01-01-1998

The Journal of clinical investigation

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

15-11-1997

Nature medicine

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

01-11-1997

Journal of chromatography. B, Biomedical sciences and applications

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

15-08-1997

Journal of pharmaceutical sciences

The functional role of P-glycoprotein in the blood-brain barrier.

01-08-1997

Seminars in oncology

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

01-08-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Successful intraperitoneal suramin treatment of peritoneal mesothelioma.

01-08-1997

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.

01-05-1997

Annals of oncology : official journal of the European Society for Medical Oncology

Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer.

01-04-1997

Proceedings of the National Academy of Sciences of the United States of America

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

04-03-1997

Cancer treatment reviews

Alternative formulations of paclitaxel.

01-03-1997

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur.

01-03-1997

Cancer treatment reviews

Growth factors in human ovarian cancer.

01-03-1997

Seminars in oncology

Carboplatin and paclitaxel in patients with advanced ovarian cancer: a dose-finding study.

01-02-1997

Cancer chemotherapy and pharmacology

The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue.

01-01-1997

British journal of cancer

Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.

01-01-1997

British journal of cancer

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

01-01-1997

Cancer chemotherapy and pharmacology

Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.

01-01-1997

Journal of pharmaceutical and biomedical analysis

The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.

01-11-1996

British journal of pharmacology

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.

01-11-1996

Journal of pharmaceutical sciences

Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244).

01-11-1996

Pharmacy world & science : PWS

Etoposide phosphate, the water soluble prodrug of etoposide.

01-10-1996