Publications

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

01-12-2000

Anti-cancer drugs

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

01-11-2000

Anti-cancer drugs

Pharmaceutical development of anticancer agents derived from marine sources.

01-11-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

01-11-2000

Clinical pharmacokinetics

Pharmacokinetically guided administration of chemotherapeutic agents.

01-11-2000

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

01-11-2000

Journal of the National Cancer Institute

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

18-10-2000

Therapeutic drug monitoring

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection.

01-10-2000

Anti-cancer drugs

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.

01-10-2000

Cancer chemotherapy and pharmacology

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens.

06-09-2000

Journal of chromatography. B, Biomedical sciences and applications

Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography.

18-08-2000

The Annals of pharmacotherapy

Cyclosporine-induced anaphylaxis.

06-08-2000

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine.

06-08-2000

Anti-cancer drugs

The clinical pharmacology of alkylating agents in high-dose chemotherapy.

01-08-2000

British journal of cancer

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export.

01-08-2000

Investigational new drugs

The oral route for the administration of cytotoxic drugs: strategies to increase the efficiency and consistency of drug delivery.

01-08-2000

Cancer chemotherapy and pharmacology

Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy.

27-07-2000

Proceedings of the National Academy of Sciences of the United States of America

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.

20-06-2000

Clinical pharmacology and therapeutics

Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods.

01-06-2000

British journal of clinical pharmacology

Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.

01-06-2000

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of oral paclitaxel.

01-06-2000

Cancer chemotherapy and pharmacology

Successful treatment with paclitaxel of a patient with metastatic extra-adrenal pheochromocytoma (paraganglioma). A case report and review of the literature.

10-05-2000

Cancer journal (Sudbury, Mass.)

High-dose chemotherapy with peripheral blood progenitor cell transplantation in the adjuvant treatment of breast cancer.

01-04-2000

Anti-cancer drugs

Docetaxel in 253 previously treated patients with progressive locally advanced or metastatic breast cancer: results of a compassionate use program in The Netherlands.

01-04-2000

Drug metabolism and disposition: the biological fate of chemicals

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

01-03-2000

Cancer chemotherapy and pharmacology

Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion.

09-02-2000

Fresenius' journal of analytical chemistry

Validated method for the determination of platinum from a liposomal source (SPI-77) in human plasma using graphite furnace Zeeman atomic absorption spectrometry.

01-02-2000

International journal of pharmaceutics

In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS.

25-01-2000

Investigational new drugs

Pharmacokinetics and metabolism of the staurosporine analogue CGP 41 251 in mice.

11-11-1999

Journal of cancer research and clinical oncology

A limited-sampling model for the pharmacokinetics of carboplatin administered in combination with paclitaxel.

01-11-1999

Analytical biochemistry

32P-postlabeling assay for the quantification of the major platinum-DNA adducts.

01-11-1999

Clinical cancer research : an official journal of the American Association for Cancer Research

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

01-11-1999

Anti-cancer drugs

Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration.

01-11-1999

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice.

01-10-1999

Proceedings of the National Academy of Sciences of the United States of America

Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.

28-09-1999

Nederlands tijdschrift voor geneeskunde

[Hyperthermic intra-peritoneal chemotherapy (HIPEC) in patients with peritoneal pseudomyxoma or peritoneal metastases of colorectal carcinoma; good preliminary results from the Netherlands Cancer Institute].

11-09-1999

British journal of cancer

Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients.

01-09-1999

Cancer chemotherapy and pharmacology

Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours.

14-08-1999

European journal of drug metabolism and pharmacokinetics

Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC).

21-07-1999

Pharmacological research

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.

01-07-1999

British journal of cancer

Oral topotecan: bioavailablity and effect of food co-administration.

01-07-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.

01-06-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.

01-06-1999

Cancer chemotherapy and pharmacology

Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study.

13-05-1999

Journal of chromatography. B, Biomedical sciences and applications

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.

30-04-1999

Cancer treatment reviews

Clinical pharmacology of anticancer agents in relation to formulations and administration routes.

01-04-1999

The Journal of pharmacology and experimental therapeutics

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein.

01-04-1999

Cancer chemotherapy and pharmacology

A single 24-hour plasma sample does not predict the carboplatin AUC from carboplatin-paclitaxel combinations or from a high-dose carboplatin-thiotepa-cyclophosphamide regimen.

01-04-1999

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.

01-03-1999

British journal of cancer

Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer.

01-03-1999