Publications

Pharmaceutical research

Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis.

01-03-2007

Nederlands tijdschrift voor geneeskunde

[Management recommendations in patients with methotrexate intoxication].

10-02-2007

Molecular and cellular biology

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.

01-02-2007

Cancer biomarkers : section A of Disease markers

SELDI-TOF MS serum protein profiles in breast cancer: assessment of robustness and validity.

01-02-2007

Investigational new drugs

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype.

01-02-2007

Laboratory investigation; a journal of technical methods and pathology

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations.

01-02-2007

International journal of pharmaceutics

EO-9 bladder instillations: formulation selection based on stability characteristics and in vitro simulation studies.

01-02-2007

Journal of pharmaceutical and biomedical analysis

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.

04-01-2007

Molecular pharmacology

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.

01-01-2007

Cancer chemotherapy and pharmacology

A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.

01-01-2007

European journal of cancer (Oxford, England : 1990)

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.

01-12-2006

Journal of mass spectrometry : JMS

Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

01-12-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Flat dosing of carboplatin is justified in adult patients with normal renal function.

01-11-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.

15-10-2006

British journal of cancer

Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer.

09-10-2006

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function.

01-10-2006

Journal of pharmacokinetics and pharmacodynamics

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam.

01-10-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel.

01-10-2006

Die Pharmazie

Pharmaceutical development, quality control, stability and compatibility of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum antineoplastic agent AP5346.

01-10-2006

British journal of cancer

A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer.

18-09-2006

Journal of mass spectrometry : JMS

Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.

01-09-2006

Cancer treatment reviews

Future opportunities in preventing cisplatin induced ototoxicity.

01-08-2006

Basic & clinical pharmacology & toxicology

Interactions of serum albumin, valproic acid and carbamazepine with the pharmacokinetics of phenytoin in cancer patients.

01-08-2006

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours.

01-08-2006

European journal of clinical pharmacology

Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.

01-08-2006

Expert review of neurotherapeutics

Blood-brain barrier and chemotherapeutic treatment of brain tumors.

01-08-2006

British journal of clinical pharmacology

Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.

01-07-2006

The Journal of pharmacology and experimental therapeutics

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

01-07-2006

Molecular diagnosis & therapy

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.

15-06-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Dose-finding phase I clinical and pharmacokinetic study of orally administered irinotecan in patients with advanced solid tumors.

15-06-2006

Drug metabolism and disposition: the biological fate of chemicals

Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes.

01-06-2006

The oncologist

Symptoms and treatment in cancer therapy-induced early menopause.

01-06-2006

Cancer chemotherapy and pharmacology

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice.

01-06-2006

British journal of cancer

High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy.

08-05-2006

Analytical biochemistry

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.

01-05-2006

European journal of clinical pharmacology

Screening for polymorphisms in the PXR gene in a Dutch population.

01-05-2006

Trends in pharmacological sciences

Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry.

01-05-2006

Analytical chemistry

Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors.

15-04-2006

World journal of gastroenterology

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry.

14-03-2006

Clinical pharmacokinetics

Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.

03-03-2006

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Relationship between cisplatin administration and the development of ototoxicity.

20-02-2006

Biomedical chromatography : BMC

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors.

01-02-2006

Clinical pharmacokinetics

Mass balance studies, with a focus on anticancer drugs.

25-01-2006

Biomedical chromatography : BMC

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry.

01-01-2006

Die Pharmazie

Compatibility and stability of the novel anticancer agent ES-285 x HCl formulated with 2-hydroxypropyl-beta-cyclodextrin in infusion devices.

01-01-2006

Trends in pharmacological sciences

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.

01-01-2006

Therapeutic drug monitoring

Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin.

01-12-2005

PDA journal of pharmaceutical science and technology

Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311.

01-12-2005

British journal of cancer

Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours.

28-11-2005

Rapid communications in mass spectrometry : RCM

Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

16-11-2005