Publications

Pharmacogenetics and genomics

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide.

01-06-2008

Clinical cancer research : an official journal of the American Association for Cancer Research

Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.

01-06-2008

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

01-06-2008

Proteomics. Clinical applications

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer.

01-06-2008

Analytical and bioanalytical chemistry

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.

01-05-2008

Nutrition and cancer

Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk.

30-04-2008

British journal of cancer

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours.

22-04-2008

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.

01-04-2008

Clinical drug investigation

Carboplatin dosage formulae can generate inaccurate predictions of Carboplatin exposure in carboplatin/paclitaxel combination regimens.

29-03-2008

Molecular pharmacology

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

01-03-2008

Antimicrobial agents and chemotherapy

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.

01-03-2008

The oncologist

Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy.

01-03-2008

Journal of pharmaceutical and biomedical analysis

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry.

13-02-2008

BMC bioinformatics

Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spectrometry data.

07-02-2008

Rapid communications in mass spectrometry : RCM

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin given intravesically.

31-01-2008

Mass spectrometry reviews

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research.

31-01-2008

BMC medical genomics

Comparing the old and new generation SELDI-TOF MS: implications for serum protein profiling.

31-01-2008

The oncologist

Application of PET/CT in the development of novel anticancer drugs.

01-01-2008

Molecular cancer therapeutics

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.

01-12-2007

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

22-11-2007

Rapid communications in mass spectrometry : RCM

Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

17-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development group.

01-11-2007

British journal of clinical pharmacology

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.

01-11-2007

The Journal of clinical investigation

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

01-11-2007

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

01-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.

01-11-2007

Cancer chemotherapy and pharmacology

Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours.

01-10-2007

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry.

01-09-2007

AAPS PharmSciTech

Development of a bladder instillation of the indoloquinone anticancer agent EO-9 using tert-butyl alcohol as lyophilization vehicle.

03-08-2007

Investigational new drugs

Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.

01-08-2007

The oncologist

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors.

01-08-2007

International archives of occupational and environmental health

Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry.

01-08-2007

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).

01-07-2007

Biomedical chromatography : BMC

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography.

01-07-2007

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.

20-06-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.

01-06-2007

Investigational new drugs

Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors.

01-06-2007

American journal of physiology. Cell physiology

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

01-06-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.

15-05-2007

Cancer chemotherapy and pharmacology

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.

01-05-2007

Cancer chemotherapy and pharmacology

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.

01-05-2007

Rapid communications in mass spectrometry : RCM

Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry.

06-04-2007

Molecular diagnosis & therapy

Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity.

03-04-2007

Pharmaceutical research

Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis.

01-03-2007

Nederlands tijdschrift voor geneeskunde

[Management recommendations in patients with methotrexate intoxication].

10-02-2007

Molecular and cellular biology

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.

01-02-2007

Cancer biomarkers : section A of Disease markers

SELDI-TOF MS serum protein profiles in breast cancer: assessment of robustness and validity.

01-02-2007

Investigational new drugs

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype.

01-02-2007