Publications

Rapid communications in mass spectrometry : RCM

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.

01-10-2009

Analytical biochemistry

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

01-10-2009

The International journal of biological markers

Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling.

30-09-2009

Human antibodies

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies.

05-09-2009

The oncologist

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature.

01-09-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.

15-08-2009

Analytical biochemistry

Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

15-08-2009

The oncologist

Clinical experience with aurora kinase inhibitors: a review.

01-08-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors.

01-07-2009

Oncology reports

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.

01-07-2009

Breast cancer research and treatment

Clinical proteomics in breast cancer: a review.

01-07-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

15-06-2009

Cancer chemotherapy and pharmacology

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

01-06-2009

Analytical and bioanalytical chemistry

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

01-06-2009

Clinical chemistry and laboratory medicine

Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).

07-05-2009

Journal of chromatography. A

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.

10-04-2009

Cancer treatment reviews

The biological and clinical role of drug transporters at the intestinal barrier.

01-04-2009

Drug metabolism and disposition: the biological fate of chemicals

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

01-04-2009

Investigational new drugs

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

01-04-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.

01-04-2009

Acta oncologica (Stockholm, Sweden)

Persistent neuropathy after treatment with cisplatin and oxaliplatin.

25-03-2009

International journal of clinical pharmacology and therapeutics

Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.

01-03-2009

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

01-03-2009

Journal of pharmaceutical and biomedical analysis

Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

20-02-2009

Cancer chemotherapy and pharmacology

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa.

01-02-2009

Journal of pharmacokinetics and pharmacodynamics

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

01-02-2009

Clinical pharmacology and therapeutics

Novel clinical trial designs for innovative therapies.

01-02-2009

Cancer biotherapy & radiopharmaceuticals

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy.

01-02-2009

Investigational new drugs

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.

01-02-2009

Therapeutic drug monitoring

Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen.

01-02-2009

Cancer treatment reviews

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment.

01-02-2009

Cancer chemotherapy and pharmacology

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.

01-01-2009

Drug metabolism and disposition: the biological fate of chemicals

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

01-01-2009

British journal of clinical pharmacology

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

01-01-2009

Current clinical pharmacology

Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

01-01-2009

BMC cancer

Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

24-12-2008

Clinical drug investigation

Ciprofloxacin strongly inhibits clozapine metabolism: two case reports.

11-12-2008

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Propofol extravasation in a breast cancer patient.

01-12-2008

Clinical cancer research : an official journal of the American Association for Cancer Research

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors.

15-11-2008

Die Pharmazie

Purity profile of the indoloquinone anticancer agent EO-9 and chemical stability of EO-9 freeze dried with 2-hydroxypropyl-beta-cyclodextrin.

01-11-2008

Pharmacogenetics and genomics

Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin.

01-11-2008

Drug development and industrial pharmacy

Complexation study of the anticancer agent EO-9 with 2-hydroxypropyl-beta-cyclodextrin.

01-10-2008

British journal of clinical pharmacology

Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin.

01-10-2008

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial.

01-10-2008

BMC clinical pharmacology

Long-term platinum retention after treatment with cisplatin and oxaliplatin.

17-09-2008

Molecular cancer therapeutics

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

01-09-2008

Drug metabolism and disposition: the biological fate of chemicals

Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice.

01-08-2008

Molecular cancer therapeutics

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.

01-08-2008

Molecular cancer therapeutics

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.

01-08-2008

Antimicrobial agents and chemotherapy

Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

01-08-2008