Publications

Current clinical pharmacology

Pharmacodynamic biomarkers in model-based drug development in oncology.

01-02-2011

Journal of pharmaceutical and biomedical analysis

Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry.

25-01-2011

Computer methods and programs in biomedicine

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

01-01-2011

Cancer chemotherapy and pharmacology

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.

01-01-2011

Analytica chimica acta

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.

17-12-2010

International journal of cancer

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

15-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages.

01-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice.

01-09-2010

Current clinical pharmacology

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents.

01-08-2010

Clinical pharmacokinetics

Clinical pharmacokinetics of therapeutic monoclonal antibodies.

01-08-2010

Current clinical pharmacology

Inducing synthetic lethality using PARP inhibitors.

01-08-2010

Journal of pharmacokinetics and pharmacodynamics

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080.

01-08-2010

Current clinical pharmacology

DNA vaccination in oncology: current status, opportunities and perspectives.

01-08-2010

Current clinical pharmacology

Personalized medicine in oncology: a personal view with myths and facts.

01-08-2010

Mass spectrometry reviews

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.

14-07-2010

Annals of oncology : official journal of the European Society for Medical Oncology

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.

01-07-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

01-07-2010

Oncology reports

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry.

01-07-2010

British journal of pharmacology

Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.

01-07-2010

Human antibodies

Pharmacokinetics of rituximab in patients with CD20 positive B-cell malignancies.

18-06-2010

International journal of pharmaceutics

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

05-05-2010

British journal of clinical pharmacology

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer.

01-05-2010

Investigational new drugs

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

01-04-2010

Molecular pharmacology

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.

01-04-2010

Investigational new drugs

Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.

01-04-2010

Oncology letters

Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer.

01-03-2010

AAPS PharmSciTech

Naked plasmid DNA formulation: effect of different disaccharides on stability after lyophilisation.

01-03-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

01-03-2010

Molecular cancer therapeutics

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

01-02-2010

Investigational new drugs

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents.

01-02-2010

Biomedical chromatography : BMC

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature.

01-01-2010

Nucleosides, nucleotides & nucleic acids

Facile small scale synthesis of nucleoside 5'-phosphate mixtures.

01-01-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.

01-01-2010

Clinical pharmacology and therapeutics

Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel.

01-01-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity.

15-12-2009

Journal of pharmaceutical and biomedical analysis

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

05-12-2009

Cancer research

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

01-12-2009

Cancer treatment reviews

High-grade glioma mouse models and their applicability for preclinical testing.

01-12-2009

Drug metabolism and disposition: the biological fate of chemicals

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.

01-12-2009

Biomedical chromatography : BMC

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.

01-12-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-11-2009

Journal of the American Society for Mass Spectrometry

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

01-11-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography.

01-11-2009

Journal of controlled release : official journal of the Controlled Release Society

DNA tattoo vaccination: effect on plasmid purity and transfection efficiency of different topoisoforms.

15-10-2009

Analytical and bioanalytical chemistry

Protein versus DNA as a marker for peripheral blood mononuclear cell counting.

01-10-2009

Rapid communications in mass spectrometry : RCM

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.

01-10-2009

Analytical biochemistry

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

01-10-2009

The International journal of biological markers

Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling.

30-09-2009

Human antibodies

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies.

05-09-2009

The oncologist

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature.

01-09-2009