Publications

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

01-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.

01-11-2007

Cancer cell

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

01-10-2007

Proceedings of the National Academy of Sciences of the United States of America

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

17-07-2007

Biomedical chromatography : BMC

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography.

01-07-2007

Investigational new drugs

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype.

01-02-2007

European journal of cancer (Oxford, England : 1990)

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.

01-12-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.

15-10-2006

Expert review of neurotherapeutics

Blood-brain barrier and chemotherapeutic treatment of brain tumors.

01-08-2006

Cold Spring Harbor symposia on quantitative biology

Genotype-phenotype relationships in a mouse model for human small-cell lung cancer.

28-07-2006

The Journal of pharmacology and experimental therapeutics

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.

01-07-2006

Cancer chemotherapy and pharmacology

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice.

01-06-2006

International journal of cancer

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.

20-09-2005

Cancer chemotherapy and pharmacology

Metabolism of docetaxel in mice.

01-09-2005

Analytical and bioanalytical chemistry

Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.

01-08-2005

Cancer research

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients.

01-04-2005

Journal of mass spectrometry : JMS

A simple and sensitive assay for the quantitative analysis of paclitaxel in human and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry.

01-12-2004

Cancer research

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.

15-08-2004

Cancer treatment reviews

Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

01-08-2004

Investigational new drugs

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice.

01-08-2004

European journal of cancer (Oxford, England : 1990)

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein.

01-05-2004

Cancer chemotherapy and pharmacology

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice.

01-02-2004

Analytical biochemistry

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.

01-01-2004

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalysis of zosuquidar trihydrochloride (LY335979) in small volumes of human and murine plasma by ion-pairing reversed-phase high-performance liquid chromatography.

05-12-2003

British journal of cancer

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

03-11-2003

Laboratory animals

Cannulation of the jugular vein in mice: a method for serial withdrawal of blood samples.

01-07-2003

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

01-07-2003

Cancer research

Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.

15-03-2003

Anti-cancer drugs

Metabolism of paclitaxel in mice.

01-03-2003

Anti-cancer drugs

Pharmacokinetics of doxorubicin and cisplatin used in intraoperative hyperthermic intrathoracic chemotherapy after cytoreductive surgery for malignant pleural mesothelioma and pleural thymoma.

01-01-2003

Cancer research

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

01-11-2002

Cancer chemotherapy and pharmacology

A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.

01-07-2002

Molecular cancer therapeutics

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

01-04-2002

Cancer chemotherapy and pharmacology

Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

01-02-2002

British journal of cancer

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.

16-11-2001

Journal of chromatography. B, Biomedical sciences and applications

Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography.

05-11-2001

Journal of chromatography. B, Biomedical sciences and applications

Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.

05-08-2001

Cancer chemotherapy and pharmacology

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.

01-04-2001

Anti-cancer drugs

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.

01-04-2001

Toxicology letters

The importance of drug-transporting P-glycoproteins in toxicology.

31-03-2001

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

01-12-2000

Anti-cancer drugs

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

01-11-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

01-11-2000

Anti-cancer drugs

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.

01-10-2000

Investigational new drugs

The oral route for the administration of cytotoxic drugs: strategies to increase the efficiency and consistency of drug delivery.

01-08-2000

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I and pharmacokinetic study of oral paclitaxel.

01-06-2000

Drug metabolism and disposition: the biological fate of chemicals

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

01-03-2000

Investigational new drugs

Pharmacokinetics and metabolism of the staurosporine analogue CGP 41 251 in mice.

11-11-1999

The Journal of clinical investigation

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.

01-11-1999

Clinical cancer research : an official journal of the American Association for Cancer Research

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

01-11-1999