Publications

Current biology : CB

Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.

22-07-2008

PloS one

The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTR.

04-06-2008

PloS one

Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

21-05-2008

Cell

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

16-05-2008

Cell division

The many faces of ubiquitinated histone H2A: insights from the DUBs.

22-04-2008

Current opinion in cell biology

Stem cell regulation by polycomb repressors: postponing commitment.

01-04-2008

Cancer cell

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

01-10-2007

Nature reviews. Cancer

Polycomb silencers control cell fate, development and cancer.

01-11-2006

The EMBO journal

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

07-06-2006

Cell cycle (Georgetown, Tex.)

Controlling stem cell proliferation: CKIs at work.

01-06-2006

Nature genetics

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster.

01-06-2006

Molecular and cellular biology

Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1.

01-12-2005

Oncogene

Retroviral insertional mutagenesis: past, present and future.

21-11-2005

Cold Spring Harbor symposia on quantitative biology

Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance.

25-08-2005

Genes & development

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

15-06-2005

Proceedings of the National Academy of Sciences of the United States of America

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.

24-05-2005

Genes & development

Epigenetics and cancer.

01-10-2004

Cell

Stem cells and cancer; the polycomb connection.

20-08-2004

Current opinion in cell biology

Polycomb complexes and silencing mechanisms.

01-06-2004

Proceedings of the National Academy of Sciences of the United States of America

Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.

04-03-2003

Nature genetics

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.

01-09-2002

The Journal of biological chemistry

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

19-07-2002

Biochimica et biophysica acta

Polycomb repression: from cellular memory to cellular proliferation and cancer.

21-06-2002

Cancer cell

RUNX: a trilogy of cancer genes.

01-04-2002

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Nature genetics

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

01-11-2000

Journal of cell science

Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.

01-12-1999

Genes & development

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

15-10-1999

Current opinion in genetics & development

The trithorax-group and polycomb-group chromatin modifiers: implications for disease.

01-06-1999

Seminars in cell & developmental biology

Cellular memory of transcriptional states by Polycomb-group proteins.

01-04-1999

Nature

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.

14-01-1999

Molecular and cellular biology

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

01-06-1998

Cellular and molecular life sciences : CMLS

Functional analysis of mouse Polycomb group genes.

01-01-1998

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

14-11-1997

Oncogene

Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.

18-08-1997

Genes & development

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

15-01-1997

Nature

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.

20-04-1995

Genes & development

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

01-04-1994

Cold Spring Harbor symposia on quantitative biology

Mouse model systems to study multistep tumorigenesis.

01-01-1994

Human molecular genetics

Characterization and chromosomal localization of the human proto-oncogene BMI-1.

01-10-1993

Nature

Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2.

26-09-1991

Cell

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.

31-05-1991

Molecular and cellular biology

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

01-02-1991

Biochimica et biophysica acta

Tumorigenesis by slow-transforming retroviruses--an update.

11-12-1990

Nature

Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice.

06-07-1989

Cell

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors.

24-02-1989

International journal of cancer. Supplement = Journal international du cancer. Supplement

Transgenic mice as a means to study synergism between oncogenes.

01-01-1989

The EMBO journal

N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.

01-01-1989