Publications

The Journal of molecular diagnostics : JMD

Mono- and Biallelic Replication-Coupled Gene Editing Discriminates Dominant-Negative and Loss-of-Function Variants of DNA Mismatch Repair Genes.

01-09-2024

Scientific reports

HideRNAs protect against CRISPR-Cas9 re-cutting after successful single base-pair gene editing.

10-06-2022

Life science alliance

The RECQL helicase prevents replication fork collapse during replication stress.

01-10-2020

Journal of medical genetics

Three-step site-directed mutagenesis screen identifies pathogenic MLH1 variants associated with Lynch syndrome.

01-05-2020

Developmental cell

WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.

23-03-2020

Scientific reports

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair.

25-01-2019

Familial cancer

Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.

01-04-2017

Proceedings of the National Academy of Sciences of the United States of America

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells.

12-04-2016

Proceedings of the National Academy of Sciences of the United States of America

Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.

12-04-2016

DNA repair

DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.

01-02-2015

Gastroenterology

Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.

01-11-2014

Cancer research

RB family tumor suppressor activity may not relate to active silencing of E2F target genes.

15-09-2014

Cell stem cell

Recreating stem cells: a novel entrance to the fountain of youth.

03-04-2009

Methods in molecular biology (Clifton, N.J.)

Generation of double-knockout embryonic stem cells.

07-03-2009