Publications

Oncogene

Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.

07-01-2010

PLoS computational biology

Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach.

01-01-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.

01-01-2010

The Journal of pathology

A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.

01-01-2010

Proc Natl Acad Sci U S A: Proceedings of the National Academy of Sciences of the United States of America

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

22-12-2009

Methods in molecular biology (Clifton, N.J.)

Studying drug resistance using genetically engineered mouse models for breast cancer.

02-12-2009

Biochimica et biophysica acta

Therapeutic options for triple-negative breast cancers with defective homologous recombination.

01-12-2009

British journal of cancer

Preclinical mouse models for BRCA1-associated breast cancer.

17-11-2009

Breast cancer research : BCR

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

28-08-2009

Clinical cancer research: an official journal of the American Association for Cancer Research

CIP2A is associated with human breast cancer aggressivity

15-08-2009

Cancer research

Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer.

15-08-2009

Breast cancer research: BRC

It's all in the details: methods in breast development and cancer

14-08-2009

Cancer Research

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival

01-08-2009

Nature protocols

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

17-06-2009

Current pharmaceutical design

Towards understanding the role of cancer-associated inflammation in chemoresistance.

13-06-2009

Cancer cell

Mammary tumorigenesis through LPA receptor signaling.

02-06-2009

Cancer research

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

15-04-2009

J Pathol.: The journal of pathology

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

01-03-2009

Breast cancer research : BCR

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.

23-12-2008

Proceedings of the National Academy of Sciences of the United States of America

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.

04-11-2008

The EMBO journal

NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin

08-10-2008

Cell cycle (Georgetown, Tex.)

Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility.

01-09-2008

Current biology : CB

Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.

22-07-2008

Clinical cancer research : an official journal of the American Association for Cancer Research

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

15-06-2008

Cell

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

16-05-2008

Cell cycle (Georgetown, Tex.)

How do real tumors become resistant to cisplatin?

15-05-2008

Nucleic acids research

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data.

01-02-2008

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Modeling therapy resistance in genetically engineered mouse cancer models.

01-01-2008

Cell cycle (Georgetown, Tex.)

What makes tumors multidrug resistant?

15-11-2007

Physiol Genomics: Physiological genomics

Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues

19-09-2007

Journal of mammary gland biology and neoplasia

Modeling metastatic breast cancer in mice.

01-09-2007

Proceedings of the National Academy of Sciences of the United States of America

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

17-07-2007

Proceedings of the National Academy of Sciences of the United States of America

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.

17-07-2007

Nature genetics

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

01-06-2007

Cancer research

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage

15-05-2007

Gastroenterology

Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease

01-04-2007

Cell

Further evidence for BRCA1 communication with the inactive X chromosome

09-03-2007

Am J Pathol: The American journal of pathology

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

01-01-2007

Experimental cel research

Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes

01-01-2007

Cancer cell

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

01-11-2006

Oncogene

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.

25-09-2006

Molecular and cellular biology

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.

01-07-2006

FASEB journal: official publication of the Federation of American Societies for Experimental Biology

Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice

01-05-2006

Nucleic acids research

Human and mouse oligonucleotide-based array CGH

16-12-2005

Cancer research

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development

15-09-2005

Genes & development

Frat is dispensable for canonical Wnt signaling in mammals.

15-02-2005

Cancer cell

Oncogene addiction: sometimes a temporary slavery.

01-12-2004

Oncogene

Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas.

12-08-2004

Nature genetics

Mutagenic insertion and chromosome engineering resource (MICER)

01-08-2004

Molecular and cellular biology

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

01-07-2004