Publications

Oncogene

p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

27-04-2017

Nature reviews. Cancer

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

01-04-2017

The Journal of pathology

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.

01-03-2017

EMBO molecular medicine

Genetically engineered mouse models in oncology research and cancer medicine.

01-02-2017

Journal of mammary gland biology and neoplasia

p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice.

01-12-2016

Nature cell biology

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

01-12-2016

Cold Spring Harbor symposia on quantitative biology

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

07-11-2016

Journal of the National Cancer Institute

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.

01-11-2016

Cancer research

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.

15-10-2016

Oncotarget

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.

27-09-2016

Cell reports

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma.

23-08-2016

J Clin Invest: The Journal of clinical investigation

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

25-07-2016

Nature

Replication fork stability confers chemoresistance in BRCA-deficient cells.

21-07-2016

Genes & development

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

15-06-2016

Nature

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

02-06-2016

Cancer research

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

01-05-2016

Molecular cell

HELB Is a Feedback Inhibitor of DNA End Resection.

04-02-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors.

01-01-2016

Nature protocols

Using the GEMM-ESC strategy to study gene function in mouse models.

01-11-2015

Annals of oncology : official journal of the European Society for Medical Oncology

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

01-10-2015

Oncogene

FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.

24-09-2015

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells.

01-09-2015

Pain

Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2⁺ breast cancer.

01-08-2015

Proceedings of the National Academy of Sciences of the United States of America

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

07-07-2015

Nature

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.

18-06-2015

Nature

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

28-05-2015

International journal of cancer

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.

15-03-2015

Genome biology

CopywriteR: DNA copy number detection from off-target sequence data.

27-02-2015

Cancer research

BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

15-02-2015

The EMBO journal

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

03-02-2015

J Pathol.: The journal of pathology

Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase

23-01-2015

J Proteome Res.: Journal of proteome research

The use of mass spectrometry imaging to predict treatment response of patient-derived xenograft models of triple-negative breast cancer

20-01-2015

Cell reports

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

20-01-2015

Cell death & disease

Suppression of BRCA1 sensitizes cells to proteasome inhibitors.

18-12-2014

Nucleic Acids Res.: Nucleic Acids research

INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

20-11-2014

Cell

Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

23-10-2014

Nature biotechnology

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping.

01-10-2014

Proceedings of the National Academy of Sciences of the United States of America

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

16-09-2014

Clinical cancer research : an official journal of the American Association for Cancer Research

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.

15-09-2014

Cancer discovery

Patient-derived xenograft models: an emerging platform for translational cancer research.

01-09-2014

PloS one

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

02-08-2014

Oncogene

Opportunities and hurdles in the treatment of BRCA1-related breast cancer.

17-07-2014

British journal of cancer

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.

27-05-2014

Breast Cancer Research: BRC

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

15-05-2014

Clinical cancer research : an official journal of the American Association for Cancer Research

Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors?

01-02-2014

EMBO molecular medicine

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

01-02-2014

Cell death and differentiation

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential.

01-02-2014

Cancer discovery

A high-throughput functional complementation assay for classification of BRCA1 missense variants.

01-10-2013

Stem Cells (Dayton, Ohio)

Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminal

01-09-2013

Stem cells (Dayton, Ohio)

Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

01-09-2013