For many cancer cases, mono-targeted drug therapy can work in the short term, but cancer often develops resistance mechanisms to escape the therapy and continue growing.
My research projects focus on identifying and studying the possible drug-resistance mechanisms that developed during mono-targeted cancer therapies. The outcome of the research can be used to develop better therapeutic approaches with alternative drug or drug combination that blocks the drug-resistance pathways and restore sensitivity to the original drug, in order to overcome drug resistance.
I hope that the knowledge that gained from my research projects can be translated from bench to clinic and benefits the cancer patients.