AMF provides the service to generate in-vitro models by manipulating our ESC clones. We have C57BL/6J and FVB ESC clones targeted with an RMCE dockingsite in the Col1a1 locus for easy exchange with any gene of interest. Furthermore, AMF has a large collection of validated GEMM-ESC clones re-derived from genetically mouse models. We can design and clone the targeting or exchange constructs and perform all ESC manipulations.
Feel free to contact us at amf@nki.nl to request a consultation for the generation of our in-vitro models.