Surgeons sometimes have difficulty identifying malignancies in tissue while operating. In order to improve precision when excising tumours, surgeon Theo Ruers will receive over €500,000 to develop an augmented reality system that adds previously recorded images of the tumour to live images on the operation monitor. If the development stage runs smoothly, he will use augmented reality in the final year of his research on colon cancer patients with liver metastases.
More fundamental is the study being conducted by Jacqueline Jacobs into DNA repair. She has been awarded a grant of over €640,000. DNA in the body's cells breaks and is repaired again all the time. When problems arise during repair, a cell can become cancerous. Dr Jacobs explains that "we do not yet have a thorough understanding of the repair process". Her research focuses on expanding this body of knowledge. "This type of fundamental research is vital for getting to the heart of DNA repair, which will give us further insights into how cancer develops. Based on that, we can improve diagnostics and treatment methods."
The Dutch Cancer Society awarded gynaecologist Nienke van Trommel almost €400,000 for a study into the treatment of cervical cancer. By giving patients chemotherapy prior to surgery, the operation can be less invasive and the cervix can be spared to a better degree. Van Trommel hopes that this will enable patients to become pregnant and carry the baby to term. She says: "We hope that this new treatment will give women the same survival chances as with surgery alone, and that their odds of having children will increase."
Gynaecological oncologist Christianne Lok will be using a grant worth over €700,000 for a research project to develop a blood test to determine whether ovarian tumours are benign or malignant, thereby preventing unnecessary surgeries.
Radiologist Astrid Scholten will be using a grant worth over €800,000 to conduct a comparative patient study into whether partial breast radiation treatment before surgery could lead to better cosmetic results than radiation after surgery.
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Onderzoeksprojecten
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Projectleider
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Bedrag
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Revealing novel modes of DNA repair control by ubiquitin(-like) reversal
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Jacqueline Jacobs
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€ 641.557
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Targeting epigenetic crosstalk in Diffuse Large B Cell Lymphoma
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Heinz Jacobs
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€ 680.397
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Augmented reality for precision surgery in cancer
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Theo Ruers
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€ 506.414
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Prediction tools for Hodgkin lymphoma patients to weigh benefits and harms of different treatment and survivorship care strategies
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Floor van Leeuwen
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€ 619.246
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INTERACTION of hypofractionated radiotherapy with targeted agents, antibodies and immunotherapy
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Monique de Jong
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€ 495.196
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OVI-DETECT; Liquid biopsies for improving the pre-operative diagnosis of ovarian cancer
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Christianne Lok
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€ 733.534
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A universal binding hub on cohesin to control the genome?
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Benjamin Rowland
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€ 601.637
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Neo-Adjuvant Chemotherapy and Less Extensive Surgery in Cervical Cancer to Preserve Fertility (CONTESSA/NEOCON-F)
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Nienke van Trommel
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€ 393.398
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Pre- versus postoperative accelerated partial breast irradiation in early stage breast cancer patients (PAPBI-2). A randomized phase III trial.
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Astrid Scholten
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€ 803.430
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The potential association between circadian disruption and hormone-related cancer risk; prospective cohort study among 59,947 female nurses
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Matti Rookus
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€ 588.529
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Young Investigator Grant
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Development of a translational ex-vivo model of 2D cells and organoids as a predictive tool for soft tissue sarcoma.
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Winan van Houdt
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€ 510.716
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Infrastructure
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ScreeninC: a national infrastructure for functional genome editing and large scale functional genomic screening
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Roderick Beijersbergen
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€ 2.275.668
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Nationwide infrastructure integrating research and health care to improve management for Dutch women with familial breast cancer risk
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Matti Rookus
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€ 1.779.418
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Research projects led by other institutes
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NKI researcher
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Study of breast cancer genes in men with metastatic prostate cancer, aimed at detecting relatives with an increased risk of getting cancer.
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Eveline Bleiker
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€ 607.471
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Evaluating and ameliorating multidisciplinary treatment of rectal cancer within the Netherlands.
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Corrie Marijnen
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€ 835.045
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