"During my final internship for my Master’s in Biomedical Sciences, I conducted research in Karin de Visser's lab. I received excellent guidance as well as the freedom to delve deeply into the material. I wanted more. After my internship I was able to start my PhD there, studying how different genetic mutations in breast cancer cells affect the immune system in cell and mouse models. One thing we observed was that one genetic mutation led to an unusually high number of a type of white blood cell called neutrophils in the bloodstream and other organs. Neutrophils are normally the body's first line of defense against foreign invaders, such as bacteria and viruses: they help fight infections. But here we saw them do the exact opposite. It seemed like the tumor had hijacked them. Instead of attacking the tumor, they blocked other immune cells, allowing the tumor to spread without resistance. When we prevent the tumor from communicating with these neutrophils, we see fewer metastases develop. We will need further research to find out whether this same process occurs in people. That's the best part of research—you’re always solving puzzles. Just when you think you put the last piece in the correct spot, you notice that three more pieces are missing. I now work at Maastricht UMC+ as a data manager, where I track lung cancer patients in clinical trials."
Danique Duits will defend her thesis on October 22.