Bioinformatician in Breast Cancer Immunology

In this position, you will integrate genomic and immunological data collected in innovative trials with combination immunotherapy in breast cancer patients. Your bioinformatic analyses will center around the prediction of response to therapy, a better understanding of the tumor-immune microenvironment and the development of novel therapeutic strategies. You will work with bulk RNA, TCR, exome and scRNA sequencing data and integrate this with clinical and pathological response data. Recently we started exploiting multiplex tissue imaging technologies and spatial transcriptomics to obtain a more in-depth picture of the cancer-immune-interactions.     

Team
The group of Marleen Kok works on Breast Cancer Immunotherapy in collaboration with the Computational Cancer Biology group of Lodewyk Wessels. You will be a key player in a translational research team with clinicians, cancer researchers, immunologists and computational scientists. Your projects will be in close collaboration with clinical PhD students and supervised by a senior post-doc with computational expertise. You will be imbedded in the department of Tumor Biology & Immunology and will be exposed to a broad spectrum of cancer immunology research. We actively collaborate with many research groups in the NKI and strongly believe in the power of ‘team science’.

NKI
The Antoni van Leeuwenhoek Hospital and the Netherlands Cancer Institute (NKI) in Amsterdam is a Comprehensive Cancer Centre combining a hospital and research laboratories in a single independent organization. The NKI accommodates 650 scientists and scientific personnel from more than 45 different countries. Research discussions, lectures and seminars in English and a large number of Dutch and non-Dutch postdocs, students and staff members contribute to the stimulating and international atmosphere of the Institute. We offer an inspiring and interactive research environment, state-of-the-art facilities, training, a competitive salary (including possibilities for tax-reduction) and housing facilities in the vicinity of the Institute. The Institute is located close to the city center of Amsterdam and the international Schiphol airport.
 

We are seeking an ambitious, creative computational biologist, with: 

• A strong interest in translational research and cancer immunology;
• A degree or expertise in bioinformatics, computer science or a related discipline;
• Experience in statistics and/or machine learning; 
• Proficiency in bioinformatics programming languages (e.g. R, Python);
• Experience with single cell sequencing, spatial transcriptomics or complex tissue imaging is a plus;
• Good cross-disciplinary collaborative and communication skills; 
• Background knowledge in biology and immunology; 
• Experience with projects involving genomics to identifying candidate targets and biomarkers is a plus.

Your career opportunities and terms of employment

• You will join a dynamic international research group;
• You will collaborate with scientists and clinicians with expertise in different disciplines; 
• Your temporary employment will be for a period of 1 year, with a possible extension; 
• The gross salary per month can range from € 2.982,- to € 4.540,- (salary group 45-50 scale), depending on your experience; 
• The terms of employment will be in accordance with the CAO Hospitals;
• In addition, you will receive a fixed end-of-year bonus (8,33%) and you will receive 8,33% holiday pay; 
• Your travel expenses will be reimbursed at € 0,23 per km; 
• Free parking at the Antoni van Leeuwenhoek is also part of the package; 
• Personnel is stimulated to use public transport and bicycle and therefore we offer an interesting arrangement for bikers; 
• Amsterdam is a stunning city with many cultural amenities. The institute is located within a 20-minute tram or bicycle ride from the center of Amsterdam and within 20 minutes from Schiphol airport by car, bus or bicycle.

Interested?
Your application letter, CV and contact information of 2 references can be attached to the application form (link) on our website. 
Ensure that your references information is attached together with your cover letter, as there is no option to submit them separately.

Apply by the 'Apply now'  button at the bottom of the page.
Take note: please respond to this vacancy only via the application button, and not via email.
Deadline: 
This vacancy is open until March 15th 2025
(Hours per week: 32-36 uur)

Want more information?
For further information please visit our home pages; 
Kok group: https://www.nki.nl/research/research-groups/marleen-kok/
Computational Cancer Biology: http://ccb.nki.nl
or contact Marleen Kok, m.kok@nki.nl 

The Netherlands Cancer Institute is an equal opportunity employer and values diversity in its workforce.